Type 1 diabetes is associated with increased cyclooxygenase- and cytokine-mediated inflammation
2005 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 28, no 6, 1371-1375 p.Article in journal (Refereed) Published
OBJECTIVE: The extent of involvement of cyclooxygenase (COX)-mediated inflammation in type 1 diabetes is unknown, and the association between the COX- and cytokine-mediated inflammatory responses in type 1 diabetes is not fully understood.
RESEARCH DESIGN AND METHODS: Plasma high-sensitivity C-reactive protein (CRP), 24-h urinary and plasma 15-keto-dihydro-prostaglandin F(2alpha) (a metabolite of prostaglandin F(2alpha) [PGF(2alpha)] and an indicator of COX-mediated inflammation), serum amyloid protein A (SAA), and interleukin (IL)-6 (indicators of inflammation) were measured in 38 subjects with type 1 diabetes and 41 healthy age- and sex-matched control subjects.
RESULTS: The inflammatory indicators (urinary 15-keto-dihydro-PGF(2alpha), P < 0.01; IL-6, P < 0.04) were increased in men with diabetes. CRP and SAA did not show any significant difference between the diabetic and the control subjects. Urinary levels of 15-keto-dihydro-PGF(2alpha) correlated with the degree of glycemic control, HbA(1c) (r = 0.42, P < 0.0005). No correlation was found between the duration of diabetes and the inflammatory biomarkers or metabolic measurements.
CONCLUSIONS: These results suggest that an early low-grade inflammatory process reflected by elevated levels of PGF(2alpha) and IL-6 is involved in type 1 diabetes. Thus, both COX- and cytokine-mediated inflammatory pathways are significantly related to type 1 diabetes.
Place, publisher, year, edition, pages
2005. Vol. 28, no 6, 1371-1375 p.
Adult, Albuminuria/epidemiology, C-Reactive Protein/*analysis, Cytokines/blood, Diabetes Mellitus; Type 1/blood/*complications/*physiopathology, Diabetic Angiopathies/epidemiology, Dinoprost/analogs & derivatives/blood, Female, Humans, Hypertension/epidemiology, Inflammation/*epidemiology, Lipids/blood, Male, Reference Values, Regression Analysis, Research Support; Non-U.S. Gov't
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-73980DOI: 10.2337/diacare.28.6.1371PubMedID: 15920054OAI: oai:DiVA.org:uu-73980DiVA: diva2:101891