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Type 1 diabetes is associated with increased cyclooxygenase- and cytokine-mediated inflammation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Clinical Nutrition)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Clinical Nutrition)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Clinical Nutrition)
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2005 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 28, no 6, 1371-1375 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: The extent of involvement of cyclooxygenase (COX)-mediated inflammation in type 1 diabetes is unknown, and the association between the COX- and cytokine-mediated inflammatory responses in type 1 diabetes is not fully understood.

RESEARCH DESIGN AND METHODS: Plasma high-sensitivity C-reactive protein (CRP), 24-h urinary and plasma 15-keto-dihydro-prostaglandin F(2alpha) (a metabolite of prostaglandin F(2alpha) [PGF(2alpha)] and an indicator of COX-mediated inflammation), serum amyloid protein A (SAA), and interleukin (IL)-6 (indicators of inflammation) were measured in 38 subjects with type 1 diabetes and 41 healthy age- and sex-matched control subjects.

RESULTS: The inflammatory indicators (urinary 15-keto-dihydro-PGF(2alpha), P < 0.01; IL-6, P < 0.04) were increased in men with diabetes. CRP and SAA did not show any significant difference between the diabetic and the control subjects. Urinary levels of 15-keto-dihydro-PGF(2alpha) correlated with the degree of glycemic control, HbA(1c) (r = 0.42, P < 0.0005). No correlation was found between the duration of diabetes and the inflammatory biomarkers or metabolic measurements.

CONCLUSIONS: These results suggest that an early low-grade inflammatory process reflected by elevated levels of PGF(2alpha) and IL-6 is involved in type 1 diabetes. Thus, both COX- and cytokine-mediated inflammatory pathways are significantly related to type 1 diabetes.

Place, publisher, year, edition, pages
2005. Vol. 28, no 6, 1371-1375 p.
Keyword [en]
Adult, Albuminuria/epidemiology, C-Reactive Protein/*analysis, Cytokines/blood, Diabetes Mellitus; Type 1/blood/*complications/*physiopathology, Diabetic Angiopathies/epidemiology, Dinoprost/analogs & derivatives/blood, Female, Humans, Hypertension/epidemiology, Inflammation/*epidemiology, Lipids/blood, Male, Reference Values, Regression Analysis, Research Support; Non-U.S. Gov't
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-73980DOI: 10.2337/diacare.28.6.1371PubMedID: 15920054OAI: oai:DiVA.org:uu-73980DiVA: diva2:101891
Available from: 2007-03-21 Created: 2007-03-21 Last updated: 2010-10-15Bibliographically approved

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Basu, SamarLarsson, AndersVessby, BengtBerne, Christian

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