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Local release of human neutrophil lipocalin (HNL), IL-8, and TNF-alpha is decreased as response to topical prednisolone treatment in distal ulcerative colitis and proctitis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2002 (English)In: Digestive Diseases and Sciences, ISSN 0163-2116, E-ISSN 1573-2568, Vol. 47, no 9, 2064-2069 p.Article in journal (Refereed) Published
Abstract [en]

The local release of human neutrophil lipocalin, considered to be highly specific for neutrophil granulocyte activation, and interleukin-8 and tumor necrosis factor-a were studied in 11 patients with distal ulcerative colitis and proctitis before and during treatment with steroid enemas. A rectal perfusion technique for sampling and specific immunoassays for analysis were used. In responders (N = 8) the concentrations of all proteins decreased during the study. There was a close correlation between human neutrophil lipocalin concentrations and treatment response. Tumor necrosis factor-a showed an initial decline in concentrations irrespective of treatment outcome and preceded the decline of human neutrophil lipocalin and interleukin-8. We conclude that decreased neutrophil degranulation is correlated with treatment outcome. Furthermore, an important role of tumor necrosis factor-a in the process of stimulating neutrophil activation and degranulation in ulcerative colitis is suggested.

Place, publisher, year, edition, pages
2002. Vol. 47, no 9, 2064-2069 p.
Keyword [en]
Acute-Phase Proteins, Anti-Inflammatory Agents/administration & dosage/*therapeutic use, Carrier Proteins/*metabolism, Colitis; Ulcerative/*drug therapy/metabolism, Enema, Humans, Interleukin-8/*metabolism, Neutrophils/*metabolism, Oncogene Proteins, Prednisolone/administration & dosage/*therapeutic use, Proctitis/*drug therapy/metabolism, Research Support; Non-U.S. Gov't, Tumor Necrosis Factor-alpha/*metabolism
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-74311DOI: 10.1023/A:1019681030784PubMedID: 12353856OAI: oai:DiVA.org:uu-74311DiVA: diva2:102221
Available from: 2007-03-14 Created: 2007-03-14 Last updated: 2017-12-14Bibliographically approved

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Sangfelt, PerCarlson, MarieXu, ShengyuanLööf, Lars

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Sangfelt, PerCarlson, MarieXu, ShengyuanLööf, Lars
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Department of Medical SciencesDepartment of Surgical SciencesCentre for Clinical Research, County of Västmanland
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