Local release of human neutrophil lipocalin (HNL), IL-8, and TNF-alpha is decreased as response to topical prednisolone treatment in distal ulcerative colitis and proctitis
2002 (English)In: Digestive Diseases and Sciences, ISSN 0163-2116, E-ISSN 1573-2568, Vol. 47, no 9, 2064-2069 p.Article in journal (Refereed) Published
The local release of human neutrophil lipocalin, considered to be highly specific for neutrophil granulocyte activation, and interleukin-8 and tumor necrosis factor-a were studied in 11 patients with distal ulcerative colitis and proctitis before and during treatment with steroid enemas. A rectal perfusion technique for sampling and specific immunoassays for analysis were used. In responders (N = 8) the concentrations of all proteins decreased during the study. There was a close correlation between human neutrophil lipocalin concentrations and treatment response. Tumor necrosis factor-a showed an initial decline in concentrations irrespective of treatment outcome and preceded the decline of human neutrophil lipocalin and interleukin-8. We conclude that decreased neutrophil degranulation is correlated with treatment outcome. Furthermore, an important role of tumor necrosis factor-a in the process of stimulating neutrophil activation and degranulation in ulcerative colitis is suggested.
Place, publisher, year, edition, pages
2002. Vol. 47, no 9, 2064-2069 p.
Acute-Phase Proteins, Anti-Inflammatory Agents/administration & dosage/*therapeutic use, Carrier Proteins/*metabolism, Colitis; Ulcerative/*drug therapy/metabolism, Enema, Humans, Interleukin-8/*metabolism, Neutrophils/*metabolism, Oncogene Proteins, Prednisolone/administration & dosage/*therapeutic use, Proctitis/*drug therapy/metabolism, Research Support; Non-U.S. Gov't, Tumor Necrosis Factor-alpha/*metabolism
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-74311DOI: 10.1023/A:1019681030784PubMedID: 12353856OAI: oai:DiVA.org:uu-74311DiVA: diva2:102221