Changes of cartilage and bone markers after intra- articular glucocorticoid treatment with and without postinjection rest in patients with rheumatoid arthritis
2005 (English)In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 64, no 12, 1750-1753 p.Article in journal (Refereed) Published
BACKGROUND: Joint immobilisation improves the therapeutic effect of intra-articular glucocorticoid injection for knee synovitis. This may be due to retarded steroid resorption by immobilisation, a procedure that also could influence cartilage and bone metabolism. OBJECTIVE: To evaluate changes in cartilage and bone turnover after intra-articular glucocorticoid treatment for knee synovitis with and without postinjection rest. METHODS: 20 patients with rheumatoid arthritis and knee synovitis were randomised to 24 hour bed rest or to normal activity after intra-articular glucocorticoid treatment. Serum and urine markers of cartilage and bone turnover were studied for two weeks. Cartilage oligomeric matrix protein (COMP) was used as a marker of cartilage turnover, osteocalcin as marker of bone formation, and deoxipyridinoline (DPD) as marker of bone resorption. RESULTS: After the glucocorticoid injection COMP levels decreased in both groups (p<0.001), but significantly more in resting patients. Serum osteocalcin levels decreased significantly (p<0.001) without any difference between the groups. DPD was unchanged in both groups. CONCLUSIONS: Intra-articular glucocorticoid treatment for knee synovitis reduced serum COMP, which suggests that such treatment may have a cartilage protective effect. The slightly larger decrease of serum COMP in the resting group may reflect a lower clearance of COMP from the joint cavity. Serum osteocalcin was temporarily reduced, indicating a reversible suppression of bone formation.
Place, publisher, year, edition, pages
2005. Vol. 64, no 12, 1750-1753 p.
Animals, Biological Markers, Blood-Brain Barrier/*physiopathology, Endotoxemia/*blood/physiopathology, Female, Hemoglobins/analysis, Male, Nerve Growth Factors/*blood, S100 Proteins/*blood, Shock; Septic/*blood/physiopathology, Swine
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-74340DOI: 10.1136/ard.2004.035022PubMedID: 15843449OAI: oai:DiVA.org:uu-74340DiVA: diva2:102250