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Changes of cartilage and bone markers after intra- articular glucocorticoid treatment with and without postinjection rest in patients with rheumatoid arthritis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Research and Development, Gävleborg. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Biokemisk struktur och funktion)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
2005 (English)In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 64, no 12, 1750-1753 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Joint immobilisation improves the therapeutic effect of intra-articular glucocorticoid injection for knee synovitis. This may be due to retarded steroid resorption by immobilisation, a procedure that also could influence cartilage and bone metabolism. OBJECTIVE: To evaluate changes in cartilage and bone turnover after intra-articular glucocorticoid treatment for knee synovitis with and without postinjection rest. METHODS: 20 patients with rheumatoid arthritis and knee synovitis were randomised to 24 hour bed rest or to normal activity after intra-articular glucocorticoid treatment. Serum and urine markers of cartilage and bone turnover were studied for two weeks. Cartilage oligomeric matrix protein (COMP) was used as a marker of cartilage turnover, osteocalcin as marker of bone formation, and deoxipyridinoline (DPD) as marker of bone resorption. RESULTS: After the glucocorticoid injection COMP levels decreased in both groups (p<0.001), but significantly more in resting patients. Serum osteocalcin levels decreased significantly (p<0.001) without any difference between the groups. DPD was unchanged in both groups. CONCLUSIONS: Intra-articular glucocorticoid treatment for knee synovitis reduced serum COMP, which suggests that such treatment may have a cartilage protective effect. The slightly larger decrease of serum COMP in the resting group may reflect a lower clearance of COMP from the joint cavity. Serum osteocalcin was temporarily reduced, indicating a reversible suppression of bone formation.

Place, publisher, year, edition, pages
2005. Vol. 64, no 12, 1750-1753 p.
Keyword [en]
Animals, Biological Markers, Blood-Brain Barrier/*physiopathology, Endotoxemia/*blood/physiopathology, Female, Hemoglobins/analysis, Male, Nerve Growth Factors/*blood, S100 Proteins/*blood, Shock; Septic/*blood/physiopathology, Swine
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-74340DOI: 10.1136/ard.2004.035022PubMedID: 15843449OAI: oai:DiVA.org:uu-74340DiVA: diva2:102250
Available from: 2007-01-04 Created: 2007-01-04 Last updated: 2010-08-13Bibliographically approved

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Weitoft, TomasLarsson, AndersRönnblom, Lars

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Centre for Research and Development, GävleborgDepartment of Medical Sciences
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