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Characterization of Surface-Modified Nanoparticles for in Vivo Biointeraction. A Sedimentation Field Flow Fractionation Study
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Surface Biotechnology. Department of Physical and Analytical Chemistry, Surface Biotechnology. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Physical and Analytical Chemistry.
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Surface Biotechnology. Department of Physical and Analytical Chemistry, Surface Biotechnology. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Physical and Analytical Chemistry.
Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmacy. Department of Physical and Analytical Chemistry, Surface Biotechnology.
Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmacy. Department of Physical and Analytical Chemistry, Surface Biotechnology.
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2005 (English)In: Analytical Chemistry, Vol. 77, 5488-5493 p.Article in journal (Refereed) Published
Abstract [en]

Sedimentation field flow fractionation (SdFFF) is an emerging high-performance analytical tool for separation and determination of size and adsorption characteristics of colloidal particles. This study demonstrates how SdFFF can be used to characterize nanoparticles prepared for in vivo applications including (1) the quantification of polymer uptake on nanoparticles where surface coverage is crucial and (2) the coupling of cell adhesive peptides containing the Arg-Gly-Asp motif (RGD). Quantitative information about polymer adhesion in order to prepare a bioinert surface and an accurate determination of ligand uptake are both of obvious importance for the understanding of, for example, relations between the number of attached molecules for biointeraction and an observed therapeutic effect. In addition, the present work highlights the necessity to perform careful characterization of commercially available particulate starting materials, in terms of size and polydispersity, prior to biological experimentation.

Place, publisher, year, edition, pages
2005. Vol. 77, 5488-5493 p.
Keyword [en]
FFF, nanoparticle, surface, modification, RGD, collodial, particles, analysis, quantification, polymer, uptake, surface, ligand, biotechnology
National Category
Physical Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-74523OAI: oai:DiVA.org:uu-74523DiVA: diva2:102433
Available from: 2007-02-13 Created: 2007-02-13 Last updated: 2011-01-11

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Andersson, MargarethaFromell, KarinArtursson, PerCaldwell, Karin

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