Slight Increase of Serum S-100B During Porcine Endotoxemic Shock May Indicate Blood-Brain Barrier Damage.
2005 (English)In: Anesth Analg, ISSN 0003-2999, Vol. 101, no 5, 1465-9 p.Article in journal (Refereed) Published
Septic shock is a condition that affects many organs, but little is known about the effects on the central nervous system. S-100B, an acidic low molecular weight protein, has attracted considerable interest as a marker for brain damage and disintegration of the blood-brain barrier. It is released into the cerebrospinal fluid and blood from brain tissue after brain damage. We studied S-100B in a porcine model of endotoxemic shock that resembles human Gram-negative septic shock. Ten piglets received IV endotoxin, and plasma samples were collected before the endotoxin infusion and each hour (1-6 h) during the endotoxin infusion. S-100B was measured by sandwich enzyme-linked immunosorbent assay. Low levels of plasma S-100B were detected, but there was a significant increase in S-100B during Hours 1-5 in comparison with the 0 values. We determined that endotoxemia causes a very small but significant increase in the levels of the widely used brain damage marker serum S-100B. However, it cannot be excluded that the increase in S-100B could be caused by release from organs other than the brain.
Place, publisher, year, edition, pages
2005. Vol. 101, no 5, 1465-9 p.
Animals, Biological Markers, Blood-Brain Barrier/*physiopathology, Endotoxemia/*blood/physiopathology, Female, Hemoglobins/analysis, Male, Nerve Growth Factors/*blood, Research Support; Non-U.S. Gov't, S100 Proteins/*blood, Shock; Septic/*blood/physiopathology, Swine
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-74701PubMedID: 16244012OAI: oai:DiVA.org:uu-74701DiVA: diva2:102611