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Slight Increase of Serum S-100B During Porcine Endotoxemic Shock May Indicate Blood-Brain Barrier Damage.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Klinisk kemi.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Anaesthesiology and Intensive Care)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Infektion. (Friman)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Klinisk kemi. (Biokemisk struktur och funktion)
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2005 (English)In: Anesth Analg, ISSN 0003-2999, Vol. 101, no 5, 1465-9 p.Article in journal (Refereed) Published
Abstract [en]

Septic shock is a condition that affects many organs, but little is known about the effects on the central nervous system. S-100B, an acidic low molecular weight protein, has attracted considerable interest as a marker for brain damage and disintegration of the blood-brain barrier. It is released into the cerebrospinal fluid and blood from brain tissue after brain damage. We studied S-100B in a porcine model of endotoxemic shock that resembles human Gram-negative septic shock. Ten piglets received IV endotoxin, and plasma samples were collected before the endotoxin infusion and each hour (1-6 h) during the endotoxin infusion. S-100B was measured by sandwich enzyme-linked immunosorbent assay. Low levels of plasma S-100B were detected, but there was a significant increase in S-100B during Hours 1-5 in comparison with the 0 values. We determined that endotoxemia causes a very small but significant increase in the levels of the widely used brain damage marker serum S-100B. However, it cannot be excluded that the increase in S-100B could be caused by release from organs other than the brain.

Place, publisher, year, edition, pages
2005. Vol. 101, no 5, 1465-9 p.
Keyword [en]
Animals, Biological Markers, Blood-Brain Barrier/*physiopathology, Endotoxemia/*blood/physiopathology, Female, Hemoglobins/analysis, Male, Nerve Growth Factors/*blood, Research Support; Non-U.S. Gov't, S100 Proteins/*blood, Shock; Septic/*blood/physiopathology, Swine
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-74701PubMedID: 16244012OAI: oai:DiVA.org:uu-74701DiVA: diva2:102611
Available from: 2007-03-07 Created: 2007-03-07 Last updated: 2015-06-12

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Larsson, AndersLipcsey, MiklósSjölin, JanEriksson, Mats B

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Department of Medical SciencesCentre for Research and Development, GävleborgDepartment of Surgical SciencesAnaesthesiology and Intensive Care
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