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Tetrahydrobiopterin in the treatment of children with autistic disorder. A double-blind placebo-controlled crossover study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. neurologi.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. BUP.ORCID iD: 0000-0003-3975-0063
Hospital Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.
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2005 (English)In: Journal of Clinical Psychopharmacology, ISSN 0271-0749, E-ISSN 1533-712X, Vol. 25, no 5, 485-489 p.Article in journal (Refereed) Published
Abstract [en]

Twelve children, all boys, aged 4 to 7 years, with a diagnosis of autistic disorder and low concentrations of spinal 6R-l-erythro-5,6,7,8-tetrahydrobiopterin (tetrahydrobiopterin) were selected to participate in a double-blind, randomized, placebo-controlled, crossover study. The children received a daily dose of 3 mg tetrahydrobiopterin per kilogram during 6 months alternating with placebo. Treatment-induced effects were assessed with the Childhood Autism Rating Scale every third month. The results showed small nonsignificant changes in the total scores of Childhood Autism Rating Scale after 3- and 6-month treatment. Post hoc analysis looking at the 3 core symptoms of autism, that is, social interaction, communication, and stereotyped behaviors, revealed a significant improvement of the social interaction score after 6 months of active treatment. In addition, a high positive correlation was found between response of the social interaction score and IQ. The results indicate a possible effect of tetrahydrobiopterin treatment.

Place, publisher, year, edition, pages
2005. Vol. 25, no 5, 485-489 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-74727OAI: oai:DiVA.org:uu-74727DiVA: diva2:102637
Available from: 2006-06-26 Created: 2006-06-26 Last updated: 2017-12-14Bibliographically approved

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Danfors, Torstenvon Knorring, Anne-LiisLångström, BengtStrömberg, BoWester, UlrikaEeg-Olofsson, Orvar

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Department of NeuroscienceSection of Nuclear Medicine and PETDepartment of Women's and Children's Health
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