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The verprolin family of proteins: Regulators of cell morphogenesis and endocytosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
2005 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 579, no 24, 5253-5259 p.Article, review/survey (Refereed) Published
Abstract [en]

The verprolin family of proteins, WIP, CR16 and WIRE/WICH, has emerged as critical regulators of cytoskeletal organisation in vertebrate cells. The founding father of the family, verprolin, was originally identified in budding yeast and later shown to be needed for actin polymerisation during polarised growth and during endocytosis. The vertebrate verprolins regulate actin dynamics either by binding directly to actin, by binding the WASP family of proteins or by binding to other actin regulating proteins. Interestingly, also the vertebrate verprolins have been implicated in endocytosis, demonstrating that most of the functional modules in this fascinating group of proteins have been conserved from yeast to man.

Place, publisher, year, edition, pages
2005. Vol. 579, no 24, 5253-5259 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-74762DOI: 10.1016/j.febslet.2005.08.053PubMedID: 16182290OAI: oai:DiVA.org:uu-74762DiVA: diva2:102672
Available from: 2005-11-14 Created: 2005-11-14 Last updated: 2011-02-28Bibliographically approved

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Aspenström, Pontus
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