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Bridging proteomics and systems biology: What are the roads to be traveled?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
2005 (English)In: Proteomics, ISSN 1615-9853, E-ISSN 1615-9861, Vol. 5, no 16, 4123-4137 p.Article in journal (Refereed) Published
Abstract [en]

The comprehensive study of proteomes has become an important part of attempts to uncover the systemic properties of biological systems. Proteomics provides data of a quality which increasingly fulfills strict requirements of systems biology for quantitative and qualitative information. Notably, proteomics can generate rich datasets that describe dynamic changes of proteomes. On the other hand, large-scale modeling requires the development of mathematic tools that are adequate for the processing of largely uncertain biological data. In this review, recent developments that pave the way for the integration of proteomics into systems biology are discussed. These developments include the standardization of data acquisition and presentation, the increased comprehensiveness of proteomics studies in description of functional status, localization and dynamics of proteins, and advanced modeling approaches.

Place, publisher, year, edition, pages
2005. Vol. 5, no 16, 4123-4137 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-74763DOI: 10.1002/pmic.200500135PubMedID: 16196099OAI: oai:DiVA.org:uu-74763DiVA: diva2:102673
Available from: 2005-11-14 Created: 2005-11-14 Last updated: 2011-02-28Bibliographically approved

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