Vesicle solubilization by alkyl sulfate surfactants: A cryo-TEM study of the vesicle to micelle transition
1996 (English)In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 179, no 1, 104-113 p.Article in journal (Other academic) Published
The solubilization of small unilamellar lecithin vesicles by some different alkyl sulfate surfactants (C10SO4-, C12SO4-, and C14SO4-) was investigated by means of light scattering and cryo-transmission electron microscopy. All surfactants were found to induce vesicle growth at subsolubilizing concentrations and a transformation into small globular lipid/surfactant mixed micelles at high surfactant concentrations. The surfactant chain length, however, was found to have a profound influence both on the amount of surfactant needed for solubilization of the lipid bilayer and on the type of structures formed during the vesicle to micelle transition. For C10SO4- a coexistence between vesicles composed of normal lamellar (L(alpha)) phase and thread-like micelles was observed, whereas during solubilization with C12SO4- and C14SO4- an intermediate, presumably holey lamellar, phase appeared before the bilayers were eventually solubilized into lipid/surfactant mixed micelles. The above observations pertain to measurements made in buffer solutions containing 150 mM NaCl. Upon decreasing the salt concentration, disk-shaped micelles, and at higher surfactant concentration thread-like micelles, frequently connected via three-way junctions, were observed during solubilization with C12SO4-.
Place, publisher, year, edition, pages
1996. Vol. 179, no 1, 104-113 p.
alkyl sulfate surfactants, vesicle solubilization, discoidal micelles, thread-like micelles, three-way junctions, holey lamellar phase, cryo-TEM
IdentifiersURN: urn:nbn:se:uu:diva-75032DOI: 10.1006/jcis.1996.0192 |ISI: A1996UG88700011OAI: oai:DiVA.org:uu-75032DiVA: diva2:102942