Logo: to the web site of Uppsala University

uu.sePublications from Uppsala University
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Association between shift work history and performance on the trail making test in middle-aged and elderly humans: the EpiHealth study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.ORCID iD: 0000-0002-8552-4510
Lund Univ, Skane Univ Hosp, Sweden CRC, Dept Hlth Sci,Div Geriatr Med, Malmö, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.ORCID iD: 0000-0003-2335-8542
Show others and affiliations
2016 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 45, p. 23-29Article in journal (Refereed) Published
Abstract [en]

Shift work has been proposed to promote cognitive disturbances in humans; however, conflicting evidence is also present. By using data from 7143 middle-aged and elderly humans (45-75 years) who participated in the Swedish EpiHealth cohort study, the present analysis sought to investigate whether self-reported shift work history would be associated with performance on the trail making test (TMT). The TMT has been proposed to be a useful neuropsychological tool to evaluate humans' executive cognitive function, which is known to decrease with age. After adjustment for potential confounders (e.g., age, education, and sleep duration), it was observed that current and recent former shift workers (worked shifts during the past 5 years) performed worse on the TMT than nonshift workers. In contrast, performance on the TMT did not differ between past shift workers (off from shift work for more than 5 years) and nonshift workers. Collectively, our results indicate that shift work history is linked to poorer performance on the TMT in a cohort of middle-aged and elderly humans.

Place, publisher, year, edition, pages
2016. Vol. 45, p. 23-29
Keywords [en]
Shift work history, Trail making test, Cohort study
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-303263DOI: 10.1016/j.neurobiolaging.2016.05.007ISI: 000381092900003PubMedID: 27459922OAI: oai:DiVA.org:uu-303263DiVA, id: diva2:1032924
Funder
Swedish Research CouncilThe Swedish Brain FoundationNovo NordiskAvailable from: 2016-10-05 Created: 2016-09-15 Last updated: 2023-09-05Bibliographically approved
In thesis
1. Metabolic Health and Cognitive Function: The Roles of Lifestyle and Shift Work
Open this publication in new window or tab >>Metabolic Health and Cognitive Function: The Roles of Lifestyle and Shift Work
2019 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The risk of cognitive impairment and metabolic disturbances increases during aging. Healthy lifestyle habits, such as a regular intake of fatty fish and adherence to the Mediterranean diet (MeDi), have been shown to slow age-related cognitive decline and decrease the risk of metabolic disturbances. Conversely, poor lifestyle habits including habitual short sleep duration as well as irregular work schedules (e.g. night shift work) have been correlated with lower cognitive performance and increased risk of having metabolic syndrome (MetS). However evidence is not conclusive regarding the above mentioned associations. The aim of this thesis was to investigate associations of diet, sleep, and shift work with metabolic health or cognitive performance in two Swedish cohorts.

In Paper I and II we examined whether the dietary intake of omega-3 fatty acids and adherence to MeDi were related to measures of brain health in elderly subjects. To this aim, we used scores from the 7-minute cognitive screening test (7MS) and brain volume determined by magnetic resonance imaging. In Paper I, self-reported dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) at age 70 was positively associated with cognitive performance and global gray matter volume at age 75. In Paper II, the fully-adjusted main analysis revealed that the MeDi score was not linked to measures of brain health. However, low intake of the MeDi component meat and meat products was associated with better performance on the 7MS and larger total brain volume.

Paper III and IV included subjects aged 45-75 years. In Paper III we demonstrated that current and recent former shift workers (including shifts outside traditional working hours during the past 5 years at the time of the survey) performed worse on the trail making test (TMT) than non-shift workers. The TMT is a test evaluating executive cognitive function, and the performance on this test decreases with age. In Paper IV, sleep duration, sleep disturbances, and sleep-disordered breathing were all linked to an increased prevalence of MetS. Some of the observed associations were age-specific. For example, whereas both short and long sleep durations were linked to a higher prevalence of MetS in younger individuals (<65 years), only long sleep duration did so in the older participants. Collectively, the findings of this thesis suggest that maintaining healthy dietary habits, having high-quality sleep, and following a regular work schedule may be recommended strategies to mitigate age-related morbidities.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2019. p. 58
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1532
Keywords
cognitive function, Mediterranean diet, omega-3 fatty acids, MRI, shift work history, sleep, metabolic syndrome
National Category
Medical and Health Sciences
Research subject
Epidemiology; Medical Science
Identifiers
urn:nbn:se:uu:diva-368737 (URN)978-91-513-0557-8 (ISBN)
Public defence
2019-03-07, A1:107a, BMC, Husargatan 3, Uppsala, 10:00 (English)
Opponent
Supervisors
Available from: 2019-02-14 Created: 2019-01-17 Last updated: 2019-02-18

Open Access in DiVA

fulltext(595 kB)627 downloads
File information
File name FULLTEXT01.pdfFile size 595 kBChecksum SHA-512
7b7d90cdc343eb69863fcc667b4082c694f7f0c68180f93740e58582699ac8f241310d262c3c1ec10711215c29c9296b895c21f5998ba79365ffa9a449acbaa5
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records

Titova, Olga ELindberg, EvaLind, LarsSchiöth, Helgi B.Benedict, Christian

Search in DiVA

By author/editor
Titova, Olga ELindberg, EvaLind, LarsSchiöth, Helgi B.Benedict, Christian
By organisation
Functional PharmacologyLung- allergy- and sleep researchCardiovascular epidemiology
In the same journal
Neurobiology of Aging
Neurology

Search outside of DiVA

GoogleGoogle Scholar
Total: 627 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 831 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf