uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
A Randomized, Comparative Study to Evaluate Efficacy and Safety of Two Injection Volumes of AbobotulinumtoxinA in Treatment of Glabellar Lines
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Dermatology and Venereology.
Goteborgs Plastikkirurgiska Ctr, Gothenburg, Sweden..
Galderma A&C, Uppsala, Sweden..
Show others and affiliations
2016 (English)In: Dermatologic Surgery, ISSN 1076-0512, E-ISSN 1524-4725, Vol. 42, no 8, 967-976 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUNDDifferent volumes of 0.9% NaCl may be used to reconstitute abobotulinumtoxinA yielding an injection volume that ranges from 0.05 to 0.1 mL per injection point for treatment of glabellar lines.OBJECTIVETo evaluate the efficacy, safety, and subject satisfaction of 2 different injection volumes to deliver the same unit dose of abobotulinumtoxinA for treatment of glabellar lines.MATERIALS AND METHODSThis randomized comparative study was conducted using 2 different reconstitution volumes to deliver a fixed unit dose of 10 Speywood units (sU) of abobotulinumtoxinA in either 0.05 mL (labeled volume) or 0.1 mL (twofold volume) per injection point. Evaluations included wrinkle severity, neurophysiological assessment by compound muscle action potential (CMAP), and subject satisfaction.RESULTSUse of either injection volume of abobotulinumtoxinA resulted in the early onset of effect, high effectiveness, and long duration of effect. The safety profile and injection pain levels were similar in both groups. The twofold injection volume was shown to be noninferior to the labeled injection volume based on CMAP results.CONCLUSIONA twofold increase in injection volume to 0.1 mL per injection point to deliver 10 sU of abobotulinumtoxinA is effective and safe.

Place, publisher, year, edition, pages
2016. Vol. 42, no 8, 967-976 p.
National Category
Dermatology and Venereal Diseases Surgery
URN: urn:nbn:se:uu:diva-304412DOI: 10.1097/DSS.0000000000000805ISI: 000382555800007PubMedID: 27399956OAI: oai:DiVA.org:uu-304412DiVA: diva2:1033149
Available from: 2016-10-05 Created: 2016-10-05 Last updated: 2016-10-05Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Punga, Anna RostedtAlimohammadi, Mohammad
By organisation
Clinical NeurophysiologyDermatology and Venereology
In the same journal
Dermatologic Surgery
Dermatology and Venereal DiseasesSurgery

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

ReferencesLink to record
Permanent link

Direct link