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Quantification of 10 elements in human cerebrospinal fluid from chronic pain patients with and without spinal cord stimulation
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
GE Healthcare Biosci, S-75148 Uppsala, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
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2016 (English)In: Journal of Trace Elements in Medicine and Biology, ISSN 0946-672X, E-ISSN 1878-3252, Vol. 37, 1-7 p.Article in journal (Refereed) Published
Abstract [en]

Neuropathic pain affects 1-10% of the general population and is caused by a lesion or disease of the somatosensory nervous system. Spinal cord stimulation (SCS), a method where implanted electrodes stimulate the spinal cord, has been successfully used to treat drug-resistant neuropathic pain, but the mechanism of action is largely unknown. Studies show that SCS changes the protein levels in CSF (cerebrospinal fluid) of pain patients. Several neurological conditions have been shown to alter the elemental composition of CSF. Therefore changes in the levels of ions and trace elements in the CSF may correspond to SCS use. This study used ICP-MS (Inductively coupled plasma mass spectrometry) and ICP-AES (Inductively coupled plasma atomic emission spectroscopy) to quantify 10 elements in CSF from chronic neuropathic pain patients using SCS. The element concentrations in CSF from patients with SCS treatment on/off, were measured. No effect on the element concentrations in CSF from treatment with SCS could be detected. Also, the elemental concentrations in pooled CSF from patients without chronic neuropathic pain was determined and compared to the patients using SCS. The concentration of the elements Ca, Sr, Na, K, P, Mg and Ti were, significantly higher in patients compared to the CSF-control.

Place, publisher, year, edition, pages
2016. Vol. 37, 1-7 p.
Keyword [en]
Chronic pain, Spinal cord stimulation, ICP-MS, ICP-AES, Trace elements, CSF
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-304549DOI: 10.1016/j.jtemb.2016.06.003ISI: 000381840800001PubMedID: 27473826OAI: oai:DiVA.org:uu-304549DiVA: diva2:1033356
Available from: 2016-10-06 Created: 2016-10-06 Last updated: 2017-11-30Bibliographically approved

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Korvela, MarcusLind, Anne-LiGordh, TorstenAndersson, MaritPettersson, Jean
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