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Proteomics of TGF-beta signaling and its impact on breast cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
2005 (English)In: Expert Review of Proteomics, ISSN 1744-8387, Vol. 2, no 6, 925-935 p.Article, review/survey (Refereed) Published
Abstract [en]

The complexity of mechanisms leading to the appearance and progression of cancer is a challenge being addressed by large-scale studies, such as proteomics. Simultaneous monitoring of thousands of proteins uncovers novel signaling mechanisms, thus revising our knowledge of tumorigenesis. Transforming growth factor (TGF)-beta is a secreted polypeptide that is known to inhibit tumor growth at the early stages of cancer, but promote metastasis at the later stages. Proteomics-based studies have significantly widened our knowledge of TGF-beta-dependent regulation of cell proliferation, apoptosis, DNA damage repair and transcription. This leads to better understanding of the TGF-beta role in human breast tumorigenesis, and opens the way for the development of novel anticancer treatments and drugs, with some of the drugs already entering clinics. This review discusses recent advances in proteomics studies of TGF-beta signaling and its contribution to the understanding and treatment of breast cancer.

Place, publisher, year, edition, pages
2005. Vol. 2, no 6, 925-935 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-75569DOI: 10.1586/14789450.2.6.925PubMedID: 16307521OAI: oai:DiVA.org:uu-75569DiVA: diva2:103480
Available from: 2006-02-13 Created: 2006-02-13 Last updated: 2011-02-28Bibliographically approved

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