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A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first-pass hepatic extraction.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
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2005 (English)In: Br J Clin Pharmacol, ISSN 0306-5251, Vol. 59, no 2, 189-98 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2005. Vol. 59, no 2, 189-98 p.
Keyword [en]
Administration; Oral, Adolescent, Adult, Antimalarials/administration & dosage/*pharmacokinetics, Artemisinins/administration & dosage/*pharmacokinetics, Biological Availability, Chromatography; High Pressure Liquid, Dose-Response Relationship; Drug, Humans, Liver/*metabolism, Male, Middle Aged, Research Support; Non-U.S. Gov't, Saliva/chemistry, Sensitivity and Specificity, Sesquiterpenes/administration & dosage/*pharmacokinetics
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URN: urn:nbn:se:uu:diva-75594PubMedID: 15676041OAI: oai:DiVA.org:uu-75594DiVA: diva2:103505
Available from: 2006-02-13 Created: 2006-02-13 Last updated: 2011-01-11

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Karlsson, Mats O

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