Platelet-Derived Growth Factor:: Normal Function, Role in Disease, and Application of PDGF Antagonists
2005 (English)In: Protein Tyrosine Kinases: From Inhibitors to Useful Drugs / [ed] D. Fabbro and F. McCormick, Totowa, NJ: Humana Press , 2005, 161-186 p.Chapter in book (Other academic)
Platelet-derived growth factor (PDGF) is a family of isoforms that stimulate the growth, survival, and motility of fibroblasts, smooth muscle cells, and other cell types. PDGF was originally identified in human platelets and purified from this source; however, subsequent studies have shown that PDGF is synthesized by a number of different cell types.
PDGF has important roles in the regulation of growth and differentiation of various mesenchymal cell types during embryonal development. In the adult, PDGF stimulates wound healing and also regulates the homeostasis of the connective tissue compartment.
Overactivity of PDGF or constitutive activation of PDGF receptors has been implicated in several disorders, including malignancies, atherosclerosis, and fibrotic conditions. Therefore, much effort has recently been devoted to the development of specific and efficient PDGF antagonists. This review will focus on the validation of PDGF antagonists in animal models and on the initial clinical studies in which PDGF antagonists have been used to treat patients.
Place, publisher, year, edition, pages
Totowa, NJ: Humana Press , 2005. 161-186 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-75653DOI: 10.1226/158829384XISBN: 1-58829-384-XOAI: oai:DiVA.org:uu-75653DiVA: diva2:103564