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Conserved Synteny Between the Ciona Genome and Human Paralogons Identifies Large Duplication Events in the Molecular Evolution of the Insulin-Relaxin Gene Family
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Neuroscience.
2006 (English)In: Molecular biology and evolution, ISSN 0737-4038, E-ISSN 1537-1719, Vol. 23, no 1, 10-22 p.Article in journal (Refereed) Published
Abstract [en]

The aims of the study were to outline the sequence of eventsthat gave rise to the vertebrate insulin-relaxin gene familyand the chromosomal regions in which they reside. We analyzedthe gene content surrounding the human insulin/relaxin geneswith respect to what family they belonged to and if the duplicationhistory of investigated families parallels the evolution ofthe insulin-relaxin family members. Markov Clustering and phylogeneticanalysis were used to determine family identity. More than 15%of the genes belonged to families that have paralogs in theregions, defining two sets of quadruplicate paralogy-regions.Thereby, the localization of insulin/relaxin genes in humanis in accordance with that regions on human chromosomes 1, 11,12, 19q (insulin/IGFs) and 1, 6p/15q, 9/5, 19p (INSLs/relaxins)were formed during two genome duplications. We compared thehuman genome with that of Ciona intestinalis, a species thatsplit from the vertebrate lineage before the two suggested genomeduplications. Two insulin-like orthologs were discovered inaddition to the already described Ci-insulin gene. Conservedsynteny between the Ciona regions hosting the insulin-like genesand the two sets of human paralogons implies their common origin.Linkage of the two human paralogons, as seen in human chromosome1, as well as the two regions hosting the Ciona insulin-likegenes, suggests that a segmental duplication gave rise to theentire region prior to the genome doublings. Thus, preservedgene content provides support that genome duplication(s) inaddition to segmental and single gene duplications shaped thegenomes of extant vertebrates.

Place, publisher, year, edition, pages
2006. Vol. 23, no 1, 10-22 p.
Keyword [en]
insulin, relaxin, gene duplication, paralogous region, Ciona intestinalis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-75761DOI: 10.1093/molbev/msj002PubMedID: 16135778OAI: oai:DiVA.org:uu-75761DiVA: diva2:103672
Available from: 2006-02-16 Created: 2006-02-16 Last updated: 2012-03-09Bibliographically approved

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Olinski, RobertLundin, Lars-GustavHallböök, Finn

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