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Influence of Tracheal Obstruction on the Efficacy of Superimposed High-frequency Jet Ventilation and Single-frequency Jet Ventilation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Politecn Milan, Dipartimento Elettron Informaz & Bioingn, I-20133 Milan, Italy..
Politecn Milan, Dipartimento Elettron Informaz & Bioingn, I-20133 Milan, Italy..
Politecn Milan, Dipartimento Elettron Informaz & Bioingn, I-20133 Milan, Italy..
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2015 (English)In: Anesthesiology, ISSN 0003-3022, E-ISSN 1528-1175, Vol. 123, no 4, 799-809 p.Article in journal (Refereed) Published
Abstract [en]

Background: Both superimposed high-frequency jet ventilation (SHFJV) and single-frequency (high-frequency) jet ventilation (HFJV) have been used with success for airway surgery, but SHFJV has been found to provide higher lung volumes and better gas exchange than HFJV in unobstructed airways. The authors systematically compared the ventilation efficacy of SHFJV and HFJV at different ventilation frequencies in a model of tracheal obstruction and describe the frequency and obstruction dependence of SHFJV efficacy. Methods: Ten anesthetized animals (weight 25 to 31.5 kg) were alternately ventilated with SHFJV and HFJV at a set of different f(HF) from 50 to 600 min(-1). Obstruction was created by insertion of interchangeable stents with ID 2 to 8 mm into the trachea. Chest wall volume was measured using optoelectronic plethysmography, airway pressures were recorded, and blood gases were analyzed repeatedly. Results: SHFJV provided greater than 1.6 times higher end-expiratory chest wall volume than HFJV, and tidal volume (V-T) was always greater than 200 ml with SHFJV. Increase of f(HF) from 50 to 600 min(-1) during HFJV resulted in a more than 30-fold V-T decrease from 112 ml (97 to 130 ml) to negligible values and resulted in severe hypoxia and hypercapnia. During SHFJV, stent ID reduction from 8 to 2 mm increased end-expiratory chest wall volume by up to 3 times from approximately 100 to 300 ml and decreased V-T by up to 4.2 times from approximately 470 to 110 ml. Oxygenation and ventilation were acceptable for 4 mm ID or more, but hypercapnia occurred with the 2 mm stent. Conclusion: In this in vivo porcine model of variable severe tracheal stenosis, SHFJV effectively increased lung volumes and maintained gas exchange and may be advantageous in severe airway obstruction.

Place, publisher, year, edition, pages
2015. Vol. 123, no 4, 799-809 p.
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Anesthesiology and Intensive Care
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URN: urn:nbn:se:uu:diva-304575DOI: 10.1097/ALN.0000000000000818ISI: 000368734600010PubMedID: 26259137OAI: oai:DiVA.org:uu-304575DiVA: diva2:1038831
Funder
Swedish Heart Lung FoundationSwedish Research Council, 5315
Available from: 2016-10-20 Created: 2016-10-06 Last updated: 2016-10-20Bibliographically approved

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Sütterlin, RobertFrykholm, PeterLarsson, Anders
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