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Two-dimensional acoustic focusing of microparticles in two-phase droplet-based microfluidic systems for improved particle positioning within spherical droplets
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. (EMBLA)ORCID iD: 0000-0002-7023-4772
Department of Biomedical Engineering, Lund University, Sweden . (EMBLA)ORCID iD: 0000-0001-7980-376X
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. Uppsala University, Science for Life Laboratory, SciLifeLab. Department of Biomedical Engineering, Lund University, Sweden . (EMBLA)ORCID iD: 0000-0002-1264-1337
2016 (English)Conference paper, Poster (Refereed)
Abstract [en]

We have fabricated a silicon-glass microfluidic two-phase droplet generator capable of generating sub 100-micrometer-sized (⌀ ൌ74 μm ± 2 μm) spherical droplets at rates up to hundreds of hertz (298 Hz ± 85 Hz). Furthermore, we have implemented a two-dimensional acoustic focusing technique into the device. Here, we show that applying the focusing to 10 μm sized polystyrene particles during the droplet generation step, results in a fourfold improvement of the particle positioning (centricity) within the generated droplets compared to the unactuated control. Finally, the efficiency of the system has been optimized by incorporating aluminum matching layers in the transducer design permitting biocompatible operational temperatures (<37°C).

Place, publisher, year, edition, pages
2016.
National Category
Engineering and Technology
Research subject
Engineering Science with specialization in Microsystems Technology
Identifiers
URN: urn:nbn:se:uu:diva-305658OAI: oai:DiVA.org:uu-305658DiVA: diva2:1038840
Conference
27th Micromechanics and Microsystems Europe Workshop (MME 2016), Cork, Ireland. August 28-30th.
Funder
Swedish Research Council
Available from: 2016-10-20 Created: 2016-10-20 Last updated: 2016-10-28Bibliographically approved

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