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Adrenal Molecular Imaging
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
2016 (English)In: IMAGING IN ENDOCRINE DISORDERS / [ed] Buchfelder M. & Guaraldi F, Basel: Karger , 2016, Vol. 45, 70-79 p.Chapter in book (Refereed)
Abstract [en]

The major workload in the field of adrenal imaging comprises patients with adrenal tumors incidentally depicted by imaging performed for other reasons than adrenal disease. These so-called 'incidentalomas' are generally managed by CT and MRI, and molecular imaging techniques are required only for a few patients. PET/CT with 18F-fluorodeoxyglucose (18F-FDG) is useful for establishing whether an adrenal metastasis is the only lesion, and therefore is available for surgical resection, or if the disease is disseminated. 18F-FDG PET/CT may be applied to differ benign from malignant incidentalomas and can be helpful in the imaging of pheochromocytoma and adrenocortical cancer (ACC). 11C-metomidate PET/CT can differentiate adrenocortical from nonadrenocortical tumors and a suspected ACC may be characterized and staged before surgery. 11C-metomidate PET/CT is currently also used to help diagnose Conn's adenomas in primary aldosteronism, but further development is needed. Scintigraphy with 123I/131I-metaiodobenzylguanidine (MIBG) remains the mainstay for molecular imaging of pheochromocytoma and is mandatory in patients for whom 131I-MIBG therapy is considered. A PET tracer for the imaging of pheochromocytoma is the norepinephrine analogue (11)C-hydroxyephedrine that can be used to characterize equivocal lesions and for the follow-up and diagnosis of recurrent malignant disease. Other specialized PET tracers for the imaging of pheochromocytoma are 18F-fluorodihydroxyphenylalanine (18F-DOPA) and 18F-fluorodopamine.

Place, publisher, year, edition, pages
Basel: Karger , 2016. Vol. 45, 70-79 p.
Series
Frontiers of Hormone Research, ISSN 0301-3073
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-305770DOI: 10.1159/000442317ISI: 000400077000008PubMedID: 27003680ISBN: 978-3-318-02738-9 (print)ISBN: 978-3-318-02737-2 (print)OAI: oai:DiVA.org:uu-305770DiVA: diva2:1039129
Note

Front Horm Res. Basel, Karger, 2016, vol 45, pp 70-79

Available from: 2016-10-21 Created: 2016-10-21 Last updated: 2017-06-12Bibliographically approved

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CiteExportLink to record
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