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Early second-trimester plasma levels of NT-proBNP in women who subsequently develop early-onset preeclampsia.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
2016 (English)In: The Journal of Maternal-Fetal & Neonatal Medicine, ISSN 1476-7058, E-ISSN 1476-4954Article in journal (Refereed) Epub ahead of print
Abstract [en]

Plasma levels of NT-proBNP are elevated in women with preeclampsia at the time of diagnosis. The objective of this case-control study was to evaluate N-terminal proBNP (NT-proBNP) in maternal plasma as an early second-trimester biomarker for prediction of early-onset preeclampsia. In early second-trimester samples, women who later developed preeclampsia at gestational age 34 wk + 0 or earlier (n = 16) had similar plasma levels of NT-proBNP (median 51.8, range 26.1-131.9 pg/ml) as women with uncomplicated pregnancy outcomes (n = 43) (53.0, 14.9-184.2 pg/ml). The early second-trimester level of NT-proBNP cannot therefore be used as a predictive biomarker of early-onset preeclampsia.

Place, publisher, year, edition, pages
2016.
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Obstetrics, Gynecology and Reproductive Medicine
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URN: urn:nbn:se:uu:diva-305825DOI: 10.1080/14767058.2016.1241992PubMedID: 27677676OAI: oai:DiVA.org:uu-305825DiVA: diva2:1039266
Available from: 2016-10-22 Created: 2016-10-22 Last updated: 2016-10-22

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Department of Women's and Children's HealthDepartment of Medical Sciences
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The Journal of Maternal-Fetal & Neonatal Medicine
Obstetrics, Gynecology and Reproductive Medicine

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