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Bridging the pharmacokinetics and pharmacodynamics of UK-279,276 across healthy volunteers and stroke patients using a mechanistically based model for target-mediated disposition.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
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2005 (English)In: Pharm Res, ISSN 0724-8741, Vol. 22, no 8, 1236-46 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2005. Vol. 22, no 8, 1236-46 p.
Keyword [en]
Antigens; CD11b/metabolism, Antigens; CD18/metabolism, Cerebrovascular Accident/drug therapy/*metabolism, Fluorescent Antibody Technique, Glycoproteins/*pharmacokinetics/therapeutic use, Half-Life, Humans, Kinetics, Leukocyte Count, Mitosis, Models; Statistical, Neutrophils/drug effects/metabolism, Receptors; Drug/drug effects, Tissue Distribution
URN: urn:nbn:se:uu:diva-76035PubMedID: 16078133OAI: oai:DiVA.org:uu-76035DiVA: diva2:103946
Available from: 2006-02-23 Created: 2006-02-23 Last updated: 2011-01-11

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