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A pharmacokinetic-pharmacodynamic model for the quantitative prediction of dofetilide clinical QT prolongation from human ether-a-go-go-related gene current inhibition data.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
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2005 (English)In: Clin Pharmacol Ther, ISSN 0009-9236, Vol. 77, no 6, 572-82 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2005. Vol. 77, no 6, 572-82 p.
Keyword [en]
Adolescent, Adult, Aged, Anti-Arrhythmia Agents/*pharmacokinetics, Cation Transport Proteins/antagonists & inhibitors/*genetics, Cell Culture Techniques, Electrocardiography, Ether-A-Go-Go Potassium Channels, Heart Conduction System/drug effects, Humans, Long QT Syndrome/genetics/*physiopathology, Middle Aged, Models; Cardiovascular, Phenethylamines/*pharmacokinetics, Potassium Channels; Voltage-Gated/antagonists & inhibitors/*genetics, Research Support; Non-U.S. Gov't, Sulfonamides/*pharmacokinetics
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URN: urn:nbn:se:uu:diva-76038PubMedID: 15961988OAI: oai:DiVA.org:uu-76038DiVA: diva2:103949
Available from: 2006-03-03 Created: 2006-03-03 Last updated: 2011-01-11

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