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Interactions of drugs and an oligonucleotide with charged membranes analyzed by immobilized liposome chromatography
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry.
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry.
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry.
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry.
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2006 (English)In: Biomedical Chromatography, Vol. 20, 83-87 p.Article in journal (Refereed) Published
Abstract [en]

We studied the effect of charged lipids or detergent on the retention of drugs and an oligonucleotide by immobilized liposome chromatography to characterize solute-membrane interactions. This is a novel approach in analysis of oligonucleotide-liposome interactions. The charged lipids (phosphatidylserine or distearoyltrimethylammoniumpropane) or detergent (sodium dodecylsulfate) interacted electrostatically in a concentration-dependent matter with the solutes. The oligonucleotide ions presumably bound to the liposomes by multipoint interactions, which was saturable. Sodium dodecylsulfate seemed to affect the drug-membrane interactions more strongly than phosphatidylserine did, probably due to different positioning in the bilayer.

Place, publisher, year, edition, pages
2006. Vol. 20, 83-87 p.
Keyword [en]
Drug partitioning, electrostatic effects, immobilized liposome chromatography, liposomes, oligonucleotide-liposome complex, phospholipid bilayers, surfactants
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:uu:diva-76213DOI: doi:10.1002/bmc.532OAI: oai:DiVA.org:uu-76213DiVA: diva2:104125
Available from: 2006-03-01 Created: 2006-03-01 Last updated: 2011-01-11

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Lundquist, AnnaEngvall, CarolineBoija, ElisabetKurtovic, SanelaChattopadhyaya, Jyoti

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Lundquist, AnnaEngvall, CarolineBoija, ElisabetKurtovic, SanelaChattopadhyaya, Jyoti
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Department of BiochemistryDepartment of Bioorganic Chemistry
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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