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Unusual genomic structure: melanocortin receptors in fugu
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
2005 (English)In: Annals of the New York Academy of Sciences, ISSN 0077-8923, E-ISSN 1749-6632, Vol. 1040, 460-463 p.Article in journal (Refereed) Published
Abstract [en]

The melanocortin (MC) receptors are found in five subtypes in mammals and chicken, while recent studies have shown that the Fugu (Takifugu rubripes) genome has only four MC receptors and the zebrafish genome has six subtypes. The MC3 receptor seems to be missing from the two closely related pufferfishes, Fugu and Tetraodon (Tetraodon nigroviridis). The MC2 and MC5 receptors in the pufferfish have introns. Moreover, these two receptors are found in a tandem that is remarkably conserved in several vertebrate species. Here, we speculate about the genomic origin of the MC receptors.

Place, publisher, year, edition, pages
New York Academy of Sciences, 2005. Vol. 1040, 460-463 p.
Keyword [en]
Evolution, GPCRs, melanocortin, MSH, ACTH
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-76248DOI: 10.1196/annals.1327.090ISI: 000230936100089PubMedID: 15891089OAI: oai:DiVA.org:uu-76248DiVA: diva2:104160
Available from: 2006-03-01 Created: 2006-03-01 Last updated: 2011-12-08Bibliographically approved

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Haitina, Tatjana

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