Pharmacological characterization of melanocortin receptors in fish suggests an important role for ACTH
2005 (English)In: Annals of the New York Academy of Sciences, ISSN 0077-8923, E-ISSN 1749-6632, Vol. 1040, no Apr, 337-9 p.Article in journal (Refereed) Published
Abstract: The melanocortin (MC) receptor subtypes have distinctive characteristic binding profiles. We found that the trout and Fugu MC4 receptors have similar affinity for α-MSH and β-MSH and a much higher affinity for ACTH than does the human MC4 receptor. The Fugu MC1 and the trout and Fugu MC5 receptors also have higher affinity for ACTH-derived peptides than α-, β-, or γ-MSH. It is tempting to speculate that ACTH-derived peptides may have played an important role as “original” ligands at the MC receptors, while the specificity of the different subtypes for the α-, β-, and γ-MSH peptides may have appeared at later stages during vertebrate evolution.
Place, publisher, year, edition, pages
2005. Vol. 1040, no Apr, 337-9 p.
evolution, GPCR, melanocortin, MSH, ACTH
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-76253DOI: 10.1196/annals.1327.055PubMedID: 15891055OAI: oai:DiVA.org:uu-76253DiVA: diva2:104165