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Pharmacological characterization of melanocortin receptors in fish suggests an important role for ACTH
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. Farmakologi 3.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. Farmakologi 3.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. Farmakologi 3.
2005 (English)In: Annals of the New York Academy of Sciences, ISSN 0077-8923, E-ISSN 1749-6632, Vol. 1040, no Apr, 337-9 p.Article in journal (Refereed) Published
Abstract [en]

Abstract: The melanocortin (MC) receptor subtypes have distinctive characteristic binding profiles. We found that the trout and Fugu MC4 receptors have similar affinity for α-MSH and β-MSH and a much higher affinity for ACTH than does the human MC4 receptor. The Fugu MC1 and the trout and Fugu MC5 receptors also have higher affinity for ACTH-derived peptides than α-, β-, or γ-MSH. It is tempting to speculate that ACTH-derived peptides may have played an important role as “original” ligands at the MC receptors, while the specificity of the different subtypes for the α-, β-, and γ-MSH peptides may have appeared at later stages during vertebrate evolution.

Place, publisher, year, edition, pages
2005. Vol. 1040, no Apr, 337-9 p.
Keyword [en]
evolution, GPCR, melanocortin, MSH, ACTH
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-76253DOI: 10.1196/annals.1327.055PubMedID: 15891055OAI: oai:DiVA.org:uu-76253DiVA: diva2:104165
Available from: 2006-03-01 Created: 2006-03-01 Last updated: 2017-12-14Bibliographically approved

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Haitina, Tatjana

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