The combined use of three widely available biochemical markers as predictor of organ failure in critically ill patients
2016 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 76, no 6, 479-485 p.Article in journal (Refereed) Published
Background: We hypothesized that lactate dehydrogenase, LDH/albumin ratio in combination with or without magnesium (Mg2+) could predict organ failure in critically ill adult patients. The aim of this study was to describe a new risk index for organ failure or mortality in critically ill patients based on a combination of these routinely available biochemical plasma biomarkers.Methods: Patients18 years admitted to the intensive care unit (ICU) were screened. Albumin and LDH were analyzed at the time of admission to ICU (n=347). Organ failure assessed with Sequential Organ Failure Assessment' (SOFA) score was used, and 30-day mortality was recorded. The predictive value of the test was calculated using the areas under the receiving operating characteristic (ROC) curve.Results: The LDH/albumin ratio was higher in patients who developed organ failure as compared to those who did not (p<0.001). The areas under the ROC curve were 0.77 both for prediction of multiple organ failure and for 30-day mortality. In a subgroup of patients (n=183) admitted to ICU from the emergency department, the predictive values were 0.86 and 0.80, respectively.Conclusion: The LDH/albumin ratio at ICU admission was associated with the development of multiple organ failure and 30-day mortality in this prospective study. The clinical value of this biomarker as a predictor of organ failure in critically ill patients is yet to be defined.
Place, publisher, year, edition, pages
2016. Vol. 76, no 6, 479-485 p.
Biomarkers, critical care, lactate dehydrogenases, multiple organ failure, organ dysfunction scores
Anesthesiology and Intensive Care
IdentifiersURN: urn:nbn:se:uu:diva-305962DOI: 10.1080/00365513.2016.1201850ISI: 000384305800007PubMedID: 27362714OAI: oai:DiVA.org:uu-305962DiVA: diva2:1043700