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Genetic susceptibility to postherniotomy pain. The influence of polymorphisms in the Mu opioid receptor, TNF-alpha, GRIK3, GCH1, BDNF and CACNA2D2 genes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care. Tampere Univ Hosp, Dept Anaesthesia, POB 2000, Tampere 33521, Finland.
CLINTEC, Karolinska Inst, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Biologisk beroendeforskning)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Biologisk beroendeforskning)
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2016 (English)In: Scandinavian Journal of Pain, ISSN 1877-8860, E-ISSN 1877-8879, Vol. 12, 1-6 p.Article in journal (Refereed) Published
Abstract [en]

Background and aims: Despite improvements in surgical technique, 5%-8% of patients undergoing herniorrhaphy still suffer from clinically relevant persistent postherniotomy pain. This is a problem at both individual and society levels. The aim of this study was to determine whether or not a single nucleotide polymorphism in a specific gene contributes to the development of persistent pain after surgery. Methods: One hundred individuals with persistent postherniotomy pain, along with 100 without pain matched for age, gender and type of surgery were identified in a previous cohort study on patients operated for groin hernia. All patients underwent a thorough sensory examination and blood samples were collected. DNA was extracted and analysed for single nucleotide polymorphism in the Mu opioid receptor, TNF-alpha, GRIK3, GCH1, BDNF and CACNA2D2 genes. Results: Patients with neuropathic pain were found to have a homozygous single nucleotide polymorph in the TNF-alpha gene significantly more often than pain-free patients (P = 0.036, one-tailed test). Conclusions: SNP in the TNF-alpha gene has a significant impact on the risk for developing PPSP. Implications: The result suggests the involvement of genetic variance in the development of pain and this requires further investigation.

Place, publisher, year, edition, pages
2016. Vol. 12, 1-6 p.
Keyword [en]
Persistent postsurgical pain, Single nucleotide polymorphism, Genetic variance, TNF-alpha, Groin hernia
National Category
Surgery
Identifiers
URN: urn:nbn:se:uu:diva-306729DOI: 10.1016/j.sjpain.2015.12.006ISI: 000383375000001OAI: oai:DiVA.org:uu-306729DiVA: diva2:1044371
Available from: 2016-11-03 Created: 2016-11-03 Last updated: 2016-11-24Bibliographically approved

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Hallberg, MathiasGrönbladh, AlfhildGordh, TorstenNyberg, Fred
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