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Neural correlates of olfactory and visual memory performance in 3D-simulated mazes after intranasal insulin application
Uniklin RWTH Aachen, Diagnost & Intervent Neuroradiol, Pauwelsstr 30, D-52074 Aachen, Germany..
Uniklin RWTH Aachen, Diagnost & Intervent Neuroradiol, Pauwelsstr 30, D-52074 Aachen, Germany..
Uniklin RWTH Aachen, Diagnost & Intervent Neuroradiol, Pauwelsstr 30, D-52074 Aachen, Germany..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
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2016 (English)In: Neurobiology of Learning and Memory, ISSN 1074-7427, E-ISSN 1095-9564, Vol. 134, no Part B, 256-263 p.Article in journal (Refereed) Published
Abstract [en]

This fMRI study intended to establish 3D-simulated mazes with olfactory and visual cues and examine the effect of intranasally applied insulin on memory performance in healthy subjects. The effect of insulin on hippocampus-dependent brain activation was explored using a double-blind and placebo-controlled design. Following intranasal administration of either insulin (40 ID) or placebo, 16 male subjects participated in two experimental MRI sessions with olfactory and visual mazes. Each maze included two separate runs. The first was an encoding maze during which subjects learned eight olfactory or eight visual cues at different target locations. The second was a recall maze during which subjects were asked to remember the target cues at spatial locations. For eleven included subjects in the fMRI analysis we were able to validate brain activation for odor perception and visuospatial tasks. However, we did not observe an enhancement of declarative memory performance in our behavioral data or hippocampal activity in response to insulin application in the fMRI analysis. It is therefore possible that intranasal insulin application is sensitive to the methodological variations e.g. timing of task execution and dose of application. Findings from this study suggest that our method of 3D-simulated mazes is feasible for studying neural correlates of olfactory and visual memory performance.

Place, publisher, year, edition, pages
2016. Vol. 134, no Part B, 256-263 p.
Keyword [en]
Olfaction, Hippocampus activation, Intranasal insulin, Spatial memory
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-306745DOI: 10.1016/j.nlm.2016.07.027ISI: 000384631500007PubMedID: 27492601OAI: oai:DiVA.org:uu-306745DiVA: diva2:1045413
Funder
Novo NordiskSwedish Research CouncilAFA InsuranceThe Swedish Brain Foundation
Available from: 2016-11-09 Created: 2016-11-03 Last updated: 2016-11-09Bibliographically approved

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