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Toll-like receptors signaling: A complex network for in B-cell lymphoid malignancies NF-kappa B activation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. CERTH, Inst Appl Biosci, Thessaloniki, Greece..
IRCCS San Raffaele Hosp, Div Expt Oncol, Milan, Italy..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. CERTH, Inst Appl Biosci, Thessaloniki, Greece..
IRCCS San Raffaele Hosp, Div Expt Oncol, Milan, Italy.;Univ Vita Salute San Raffaele, Milan, Italy..
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2016 (English)In: Seminars in Cancer Biology, ISSN 1044-579X, E-ISSN 1096-3650, Vol. 39, 15-25 p.Article, review/survey (Refereed) Published
Abstract [en]

Malignancies of mature B cells are quite distinctive in originating from well-differentiated cells. Hence, it is not paradoxical that, similar to their normal counterparts, most mature B cell lymphoma subtypes are critically dependent on microenvironmental cues. Such external signals are sensed by various receptors present on the malignant cells, including the Toll-like receptors (TLRs), eliciting a range of cellular responses, including proliferation but also anergy and apoptosis, often with disease-specific patterns. Critically, the TLR signaling pathways are intertwined with other receptor pathways in malignant B cells, most notably the B-cell receptor pathway, and converge on NF-kappa B, leading to its activation. In the present review, we summarize the literature on TLR expression and functionality and its impact on NF-kappa B activation in different B cell malignancies including chronic lymphocytic leukemia where TLR9 induces activation, cell proliferation and chemoresistance in a proportion of patients while apoptosis can be induced in others. Additionally, we also discuss the therapeutic potential of strategies targeting TLR signaling in lymphoma.

Place, publisher, year, edition, pages
2016. Vol. 39, 15-25 p.
Keyword [en]
Toll-like receptors, Lymphoma, Chronic lymphocytic leukemia, NF-kappa B, IRAK inhibitors
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-307432DOI: 10.1016/j.semcancer.2016.07.001ISI: 000384862900003PubMedID: 27402288OAI: oai:DiVA.org:uu-307432DiVA: diva2:1046992
Funder
EU, European Research Council, 692298
Available from: 2016-11-16 Created: 2016-11-16 Last updated: 2016-11-16Bibliographically approved

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