Toll-like receptors signaling: A complex network for in B-cell lymphoid malignancies NF-kappa B activation
2016 (English)In: Seminars in Cancer Biology, ISSN 1044-579X, E-ISSN 1096-3650, Vol. 39, 15-25 p.Article, review/survey (Refereed) Published
Malignancies of mature B cells are quite distinctive in originating from well-differentiated cells. Hence, it is not paradoxical that, similar to their normal counterparts, most mature B cell lymphoma subtypes are critically dependent on microenvironmental cues. Such external signals are sensed by various receptors present on the malignant cells, including the Toll-like receptors (TLRs), eliciting a range of cellular responses, including proliferation but also anergy and apoptosis, often with disease-specific patterns. Critically, the TLR signaling pathways are intertwined with other receptor pathways in malignant B cells, most notably the B-cell receptor pathway, and converge on NF-kappa B, leading to its activation. In the present review, we summarize the literature on TLR expression and functionality and its impact on NF-kappa B activation in different B cell malignancies including chronic lymphocytic leukemia where TLR9 induces activation, cell proliferation and chemoresistance in a proportion of patients while apoptosis can be induced in others. Additionally, we also discuss the therapeutic potential of strategies targeting TLR signaling in lymphoma.
Place, publisher, year, edition, pages
2016. Vol. 39, 15-25 p.
Toll-like receptors, Lymphoma, Chronic lymphocytic leukemia, NF-kappa B, IRAK inhibitors
Cancer and Oncology
IdentifiersURN: urn:nbn:se:uu:diva-307432DOI: 10.1016/j.semcancer.2016.07.001ISI: 000384862900003PubMedID: 27402288OAI: oai:DiVA.org:uu-307432DiVA: diva2:1046992
FunderEU, European Research Council, 692298