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Biophysics in drug discovery: impact, challenges and opportunities
NovAliX, Blvd Sebastien Brant, F-67405 Illkirch Graffenstaden, France.;Univ Strasbourg, Inst Genet & Biol Mol & Cellulaire, CNRS UMR7104, INSERM U964, 1 Rue Laurent Fries,BP10142, F-67404 Illkirch Graffenstaden, France.;RiboStruct, 15 Rue Neuve, F-67540 Ostwald, France..
GlaxoSmithKline R&D, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England..
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Biochemistry. Uppsala University, Science for Life Laboratory, SciLifeLab. Beact AB, Uppsala Business Pk, S-75450 Uppsala, Sweden..
Bayer Pharma AG, Mullerstr 178, D-13353 Berlin, Germany..
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2016 (English)In: Nature reviews. Drug discovery, ISSN 1474-1776, E-ISSN 1474-1784, Vol. 15, no 10, 679-698 p.Article, review/survey (Refereed) Published
Abstract [en]

Over the past 25 years, biophysical technologies such as X-ray crystallography, nuclear magnetic resonance spectroscopy, surface plasmon resonance spectroscopy and isothermal titration calorimetry have become key components of drug discovery platforms in many pharmaceutical companies and academic laboratories. There have been great improvements in the speed, sensitivity and range of possible measurements, providing high-resolution mechanistic, kinetic, thermodynamic and structural information on compound target interactions. This Review provides a framework to understand this evolution by describing the key biophysical methods, the information they can provide and the ways in which they can be applied at different stages of the drug discovery process. We also discuss the challenges for current technologies and future opportunities to use biophysical methods to solve drug discovery problems.

Place, publisher, year, edition, pages
2016. Vol. 15, no 10, 679-698 p.
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Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
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URN: urn:nbn:se:uu:diva-307428DOI: 10.1038/nrd.2016.123ISI: 000384964300016PubMedID: 27516170OAI: oai:DiVA.org:uu-307428DiVA: diva2:1046999
Available from: 2016-11-16 Created: 2016-11-16 Last updated: 2016-11-16Bibliographically approved

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Danielson, U. Helena
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BiochemistryScience for Life Laboratory, SciLifeLab
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