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Signaling Receptors for TGF-beta Family Members
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2016 (English)In: Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, E-ISSN 1943-0264, Vol. 8, no 8, a022053Article in journal (Refereed) Published
Abstract [en]

Transforming growth factor beta (TGF-beta) family members signal via heterotetrameric complexes of type I and type II dual specificity kinase receptors. The activation and stability of the receptors are controlled by posttranslational modifications, such as phosphorylation, ubiquitylation, sumoylation, and neddylation, as well as by interaction with other proteins at the cell surface and in the cytoplasm. Activation of TGF-beta receptors induces signaling via formation of Smad complexes that are translocated to the nucleus where they act as transcription factors, as well as via non-Smad pathways, including the Erk1/2, JNK and p38 MAP kinase pathways, and the Src tyrosine kinase, phosphatidylinositol 30-kinase, and Rho GTPases.

Place, publisher, year, edition, pages
2016. Vol. 8, no 8, a022053
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:uu:diva-307448DOI: 10.1101/cshperspect.a022053ISI: 000384832100002OAI: oai:DiVA.org:uu-307448DiVA: diva2:1047266
Funder
Swedish Cancer SocietySwedish Research CouncilEU, FP7, Seventh Framework Programme
Available from: 2016-11-17 Created: 2016-11-16 Last updated: 2016-11-17Bibliographically approved

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Heldin, Carl-HenrikMoustakas, Aristidis
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Science for Life Laboratory, SciLifeLabLudwig Institute for Cancer ResearchDepartment of Medical Biochemistry and Microbiology
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Cold Spring Harbor Perspectives in Biology
Cell Biology

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