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Electrostatic Swelling Transitions in Surface-Bound Microgels
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
KTH Royal Inst Technol, Sch Chem Sci & Engn, Dept Surface & Corros Sci, SE-10044 Stockholm, Sweden.;IMDEA Nanosci, Inst Adv Studies, Madrid 28049, Spain..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Univ Manchester, Sch Mat, MSS Tower, Manchester M13 9PL, Lancs, England..
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2016 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 8, no 40, p. 27129-27139Article in journal (Refereed) Published
Abstract [en]

Herein, electrostatic swelling transitions of poly (ethyl acrylate-co-methacrylic acid) microgels covalently bound to silica surfaces are investigated. Confined at a solid surface, microgel swelling is anisotropically hindered and the structure is flattened to an extent dictated by pH and microgel composition. Microgel deformation under applied load is also shown to depend on microgel charge density, with the highest deformation observed at intermediate charge densities. Two modes of microgel deformation under load were observed, one elastic and one viscoelastic, related to polymer strand deformation and displacement of trapped water, respectively. Results on polymer strand dynamics reveal that the microgels are highly dynamic, as the number of strand-tip interaction points increases 4-fold during a 10 s contact time. Furthermore, finite element modeling captures these effects qualitatively and shows that stress propagation in the microgel network decays locally at the rim of contact with a solid interface or close to the tip probe. Taken together, the results demonstrate a delicate interplay between the surface and microgel which determines the structure and nanomechanical properties of the latter and needs to be controlled in applications of systems such as pH-responsive surface coatings in biomaterials.

Place, publisher, year, edition, pages
2016. Vol. 8, no 40, p. 27129-27139
Keywords [en]
atomic force microscopy, finite element method, microgel, pH-responsive, quartz crystal microbalance, surface-bound
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:uu:diva-307540DOI: 10.1021/acsami.6b09751ISI: 000385469000081PubMedID: 27644921OAI: oai:DiVA.org:uu-307540DiVA, id: diva2:1047312
Funder
Swedish Research Council, 2012-1842 2013-4384Knut and Alice Wallenberg Foundation, KAW 2012.0078Available from: 2016-11-17 Created: 2016-11-17 Last updated: 2017-11-29Bibliographically approved

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Nyström, LinaFrenning, GöranMalmsten, Martin
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