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Low-dose developmental exposure to bisphenol A alters the femoral bone geometry in wistar rats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
Tech Univ Denmark, Div Diet Dis Prevent & Toxicol, Morkhoj Bygade 19, DK-2860 Soborg, Denmark..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology.
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2016 (English)In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 164, 339-346 p.Article in journal (Refereed) Published
Abstract [en]

Background: Bisphenol A (BPA) is a chemical produced in large volumes for use in manufacturing of consumer products and industrial applications, and an endocrine disruptor known to affect several hormonal systems. Bone produces hormones and is additionally a sensitive hormone target tissue, and is thus potentially sensitive to low doses of endocrine disruptors such as BPA, especially during development. Methods: 110 pregnant Wistar rats were gavaged with 0; 25 mu g; 250 mu g; 5000 mu g or 50,000 mu g BPA/kg bodyweight (bw)/day from gestational day 7 until weaning at postnatal day 22. The three-month-old offspring were sacrificed and right femurs collected for length measurements, geometrical measurements by peripheral quantitative computed tomography (pQCT), as well as for analyses of biomechanical properties using the three-point-bending method. Results: The femur was elongated in female offspring of dams exposed to 25 or 5000 mu g BPA/kg bw/day (1.8% and 2.1%, respectively), and increased cortical thickness (4.7%) was observed in male offspring of dams exposed to 25 mu g BPA/kg bw/day, compared to controls (p < 0.005). The biomechanical properties of the bone were not significantly altered. Conclusions: In utero and lactational exposure to the lowest BPA dose used in this study altered femoral geometry in both male and female offspring. This was observed at 25 mu g BPA/kg bw/day, a dose lower than the Human Equivalent Dose (HED) applied by EFSA to set a temporary TDI (609 mu g BPA/kg bw/day), and far lower than the No-Observed-Adverse-Effect-Level (NOAEL) (5000 mu g BPA/kg bw/day) on which the US FDA TDI is based.

Place, publisher, year, edition, pages
2016. Vol. 164, 339-346 p.
Keyword [en]
Bisphenol A (BPA), Endocrine disrupting chemicals (EDCs), Low dose effects, Developmental exposure, Bone geometry, Bone biomechanics
National Category
Orthopedics Developmental Biology
Identifiers
URN: urn:nbn:se:uu:diva-307506DOI: 10.1016/j.chemosphere.2016.08.114ISI: 000385318200040PubMedID: 27592323OAI: oai:DiVA.org:uu-307506DiVA: diva2:1048209
Funder
Swedish Research Council Formas, 216-2009-972 216-2012-475
Available from: 2016-11-21 Created: 2016-11-17 Last updated: 2016-11-21Bibliographically approved

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Lejonklou, Margareta H.Örberg, JanShen, LingLarsson, SuneLind, P. Monica
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