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Diabetes Prevention Through Antiviral Treatment in Biobreeding Rats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Karolinska Univ Hosp, Dept Pathol, Stockholm, Sweden..
Karolinska Inst, Rolf Luft Res Ctr Diabet & Endocrinol, Stockholm, Sweden..
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2016 (English)In: Viral immunology, ISSN 0882-8245, E-ISSN 1557-8976, Vol. 29, no 8, 452-458 p.Article in journal (Refereed) Published
Abstract [en]

A picornavirus (Ljungan virus) has been associated with diabetes in its wild rodent reservoir and in diabetesprone biobreeding (DP-BB) rats. We attempted to alter the development of diabetes in DP-BB rats using two anti-picornavirus compounds (pleconaril and APO-N039), singly or in combination. Antiviral therapy was initiated 2 weeks before expected onset of diabetes. Pleconaril or APO-N039 alone did not affect the debut of diabetes. However, animals receiving a combination of both compounds were protected for at least the entire period of treatment (4 weeks after expected time of diabetes onset). Immunohistochemistry demonstrated that the presence and distribution of virus antigen in the pancreatic islets coincided with the clinical status of the animal. Data indicate that a treatable picornavirus can be involved in the cellular assault resulting in diabetes and in these cases the disease mechanism appears to involve a virus present in the pancreatic beta cell mass itself.

Place, publisher, year, edition, pages
2016. Vol. 29, no 8, 452-458 p.
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Infectious Medicine
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URN: urn:nbn:se:uu:diva-307744DOI: 10.1089/vim.2016.0063ISI: 000385391300002PubMedID: 27505258OAI: oai:DiVA.org:uu-307744DiVA: diva2:1048365
Available from: 2016-11-21 Created: 2016-11-21 Last updated: 2016-11-21Bibliographically approved

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Arbrandt, Gustav
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