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Lymphatic vascular morphogenesis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Cancer and Vascular Biology.ORCID iD: 0000-0002-9338-1257
2014 (English)In: Molecular Mechanisms of Angiogenesis: From Ontogenesis to Oncogenesis, Springer Publishing Company, 2014, 25-44 p.Chapter in book (Refereed)
Abstract [en]

Lymphatic vessels participate in tissue homeostasis and immune surveillance by draining excess fluid and immune cells from tissues to blood circulation. Impaired lymphatic function can lead to tissue swelling, or lymphoedema, and associated complications, such as chronic inflammation and fat accumulation. The critical role of lymphatic vessels in a number of pathological conditions, including tumour metastasis, has led to an interest in identifying signalling pathways regulating lymphatic vessel development and growth. Here, we review the current knowledge on the molecular mechanisms of lymphatic development and how lymphatic vasculature contributes to diseases.

Place, publisher, year, edition, pages
Springer Publishing Company, 2014. 25-44 p.
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-307102DOI: 10.1007/978-2-8178-0466-8_2ScopusID: 2-s2.0-84930024214ISBN: 9782817804668ISBN: 2817804651ISBN: 9782817804651OAI: oai:DiVA.org:uu-307102DiVA: diva2:1048660
Available from: 2016-11-21 Created: 2016-11-08 Last updated: 2016-11-21Bibliographically approved

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Mäkinen, Taija
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