Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma
2016 (English)In: Cancer Cell, ISSN 1535-6108, E-ISSN 1878-3686, Vol. 30, no 1, 27-42 p.Article in journal (Refereed) Published
Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas and showed that NMIBC can be subgrouped into three major classes with basal-and luminal-like characteristics and different clinical outcomes. Large differences in biological processes such as the cell cycle, epithelial-mesenchymal transition, and differentiation were observed. Analysis of transcript variants revealed frequent mutations in genes encoding proteins involved in chromatin organization and cytoskeletal functions. Furthermore, mutations in well-known cancer driver genes (e.g., TP53 and ERBB2) were primarily found in high-risk tumors, together with APOBEC-related mutational signatures. The identification of subclasses in NMIBC may offer better prognostication and treatment selection based on subclass assignment.
Place, publisher, year, edition, pages
2016. Vol. 30, no 1, 27-42 p.
Cancer and Oncology Urology and Nephrology Cell and Molecular Biology Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-308263DOI: 10.1016/j.ccell.2016.05.004ISI: 000380077100010PubMedID: 27321955OAI: oai:DiVA.org:uu-308263DiVA: diva2:1049306
FunderDanish National Research FoundationEU, FP7, Seventh Framework Programme, 201663