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Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma
Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark..
Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark..
Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark..
Univ Autonoma Barcelona, Fundacio Puigvert, Sect Pathol, Barcelona 08025, Spain..
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2016 (English)In: Cancer Cell, ISSN 1535-6108, E-ISSN 1878-3686, Vol. 30, no 1, 27-42 p.Article in journal (Refereed) Published
Abstract [en]

Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas and showed that NMIBC can be subgrouped into three major classes with basal-and luminal-like characteristics and different clinical outcomes. Large differences in biological processes such as the cell cycle, epithelial-mesenchymal transition, and differentiation were observed. Analysis of transcript variants revealed frequent mutations in genes encoding proteins involved in chromatin organization and cytoskeletal functions. Furthermore, mutations in well-known cancer driver genes (e.g., TP53 and ERBB2) were primarily found in high-risk tumors, together with APOBEC-related mutational signatures. The identification of subclasses in NMIBC may offer better prognostication and treatment selection based on subclass assignment.

Place, publisher, year, edition, pages
2016. Vol. 30, no 1, 27-42 p.
National Category
Cancer and Oncology Urology and Nephrology Cell and Molecular Biology Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-308263DOI: 10.1016/j.ccell.2016.05.004ISI: 000380077100010PubMedID: 27321955OAI: oai:DiVA.org:uu-308263DiVA: diva2:1049306
Funder
Danish National Research FoundationEU, FP7, Seventh Framework Programme, 201663
Available from: 2016-11-24 Created: 2016-11-24 Last updated: 2016-12-02Bibliographically approved

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