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Pre- and Postnatal Exposure to Parental Smoking and Allergic Disease Through Adolescence
Stockholm South Gen Hosp, Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
Stockholm South Gen Hosp, Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
Stockholm South Gen Hosp, Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden..ORCID iD: 0000-0002-9701-1130
Stockholm South Gen Hosp, Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Karolinska Inst, Stockholm South Gen Hosp, Dept Clin Sci & Educ, Stockholm, Sweden..
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2014 (English)In: Pediatrics, ISSN 0031-4005, E-ISSN 1098-4275, Vol. 134, no 3, 428-434 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To examine the role of prenatal and postnatal second-hand tobacco smoke (SHS) exposure on asthma, rhinitis, and eczema development up to 16 years of age. METHODS: A birth cohort of 4089 children was followed for 16 years. Information on parental smoking habits, lifestyle factors, and symptoms of allergic disease was gathered using repeated parental questionnaires. Generalized estimating equations assessed the overall and age-specific associations between SHS exposure and allergic disease at ages 1 to 16 years. RESULTS: Exposure to SHS in utero was associated with an overall elevated risk of developing asthma up to 16 years (odds ratio [OR] = 1.45; 95% confidence interval [CI], 1.15-1.83) but not for rhinitis or eczema. After additional adjustment for parental smoking throughout childhood, excess overall risks for asthma remained statistically significant. Moreover, a dose-dependent pattern with SHS was observed. Exposure to SHS during infancy was associated with an overall elevated risk of asthma (OR = 1.23; 95% CI, 1.01-1.51), rhinitis (OR = 1.18; 95% CI, 1.01-1.39), and eczema (OR = 1.26; 95% CI, 1.09-1.45) up to 16 years. When age-specific associations were examined, the elevated risks related to SHS exposure in utero or during infancy were mostly confined to early childhood for asthma and rhinitis, whereas the excess risk of eczema appeared greatest at later ages. CONCLUSIONS: Our findings indicate that early SHS exposure, in utero or during infancy, influences the development of allergic disease up to adolescence. Excess risks for asthma and rhinitis were seen primarily in early childhood, whereas those for eczema occurred at later ages.

Place, publisher, year, edition, pages
2014. Vol. 134, no 3, 428-434 p.
Keyword [en]
asthma, rhinitis, eczema, allergy, children, tobacco smoking, cohort study
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-306334DOI: 10.1542/peds.2014-0427ISI: 000341362600041PubMedID: 25136039OAI: oai:DiVA.org:uu-306334DiVA: diva2:1049378
Funder
Swedish Research CouncilSwedish Heart Lung FoundationSwedish Research Council FormasSwedish Asthma and Allergy AssociationStockholm County Council
Available from: 2016-11-24 Created: 2016-10-27 Last updated: 2016-11-24Bibliographically approved

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Pershagen, GoranWickman, Magnus
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