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Outcome of the Swedish Nationwide Abdominal Aortic Aneurysm Screening Program
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
Karolinska Inst Sodersjukhuset, Dept Surg, Stockholm, Sweden; Karolinska Inst Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.
Skane Univ Hosp, Dept Vasc Dis, Malmo, Sweden.
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2016 (English)In: Circulation, ISSN 0009-7322, E-ISSN 1524-4539, Vol. 134, no 16, 1141-1148 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: A general abdominal aortic aneurysm (AAA) screening program, targeting 65-year-old men, has gradually been introduced in Sweden since 2006 and reached nationwide coverage in 2015. The aim of this study was to determine the outcome of this program.

METHODS: Data on the number of invited and examined men, screening-detected AAAs, AAAs operated on, and surgical outcome were retrieved from all 21 Swedish counties for the years 2006 through 2014. AAA-specific mortality data were retrieved from the Swedish Cause of Death Registry. A linear regression analysis was used to estimate the effect on AAA-specific mortality among all men ≥65 years of age for the observed time period. The long-term effects were projected by using a validated Markov model.

RESULTS: Of 302 957 men aged 65 years invited, 84% attended. The prevalence of screening-detected AAA was 1.5%. After a mean of 4.5 years, 29% of patients with AAA had been operated on, with a 30-day mortality rate of 0.9% (1.3% after open repair and 0.3% after endovascular repair, P<0.001). The introduction of screening was associated with a significant reduction in AAA-specific mortality (mean, 4.0% per year of screening, P=0.020). The number needed to screen and the number needed to operate on to prevent 1 premature death were 667 and 1.5, respectively. With a total population of 9.5 million, the Swedish national AAA-screening program was predicted to annually prevent 90 premature deaths from AAA and to gain 577 quality-adjusted life-years. The incremental cost-efficiency ratio was estimated to be €7770 per quality-adjusted life-years.

CONCLUSIONS: Screening 65-year-old men for AAA is an effective preventive health measure and is highly cost-effective in a contemporary setting. These findings confirm the results from earlier randomized controlled trials and model studies in a large population-based setting of the importance for future healthcare decision making.

Place, publisher, year, edition, pages
2016. Vol. 134, no 16, 1141-1148 p.
National Category
Cardiac and Cardiovascular Systems
URN: urn:nbn:se:uu:diva-308344DOI: 10.1161/CIRCULATIONAHA.116.022305ISI: 000386483600009PubMedID: 27630132OAI: oai:DiVA.org:uu-308344DiVA: diva2:1049441
Available from: 2016-11-24 Created: 2016-11-24 Last updated: 2016-12-01Bibliographically approved

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