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Fathering of Dizygotic Twins and Risk of Prostate Cancer: Nationwide, Population-Based Case-Control Study
Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden..
Univ Uppsala Hosp, Reg Canc Ctr, Uppsala, Sweden..
Karolinska Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden..
Ryhov Cty Hosp, Dept Urol, Jonkoping, Sweden..
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2014 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, no 10, e110506Article in journal (Refereed) Published
Abstract [en]

Background: An association between male fertility and risk of prostate cancer has been suggested, possibly through lower androgen levels in subfertile men. We evaluated male fertility in relation to risk of prostate cancer by assessing the frequency of fathering of dizygotic twins, a marker of high fertility, among cases of prostate cancer and controls. Methods: We performed a case-control study in Prostate Cancer data Base Sweden (PCBaSe), a nationwide, population-based cohort. PCBaSe was linked to the Swedish twin register for information on zygosity for same-sex twins and to other nationwide health care registers and demographic databases for information on socioeconomic factors, comorbidity, and tumor characteristics for 96 301 prostate cancer cases and 378 583 matched controls. To account for the influence of in vitro fertilization on dizygotic twinning, analyses were restricted to men who had fathered children before 1991, when in vitro fertilization was still uncommon in Sweden. Results: 1 112 cases and 4 538 controls had fathered dizygotic twins. Men with dizygotic twins had no increased risk of prostate cancer compared to fathers of singletons; neither for total prostate cancer odds ratio (OR) 0.95(95% CI 0.89-1.02), nor for any risk category, OR 0.97 (95% CI 0.84-1.12) for low-risk disease, and OR 1.04 (95% CI 0.90-1.22) for metastatic disease. Conclusion: The lack of association between fathering of dizygotic twins and prostate cancer risk give no support for an association between male fertility and prostate cancer risk.

Place, publisher, year, edition, pages
2014. Vol. 9, no 10, e110506
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-306324DOI: 10.1371/journal.pone.0110506ISI: 000343674800049PubMedID: 25337702OAI: oai:DiVA.org:uu-306324DiVA: diva2:1049478
Funder
Swedish Research Council, 825-2010-5950Swedish Cancer Society, 11 0471
Available from: 2016-11-24 Created: 2016-10-27 Last updated: 2016-11-24Bibliographically approved

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