uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Long-term persistence of resistant Enterococcus species after antibiotics to eradicate Helicobacter pylori
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
Show others and affiliations
2003 (English)In: Annals of Internal Medicine, ISSN 0003-4819, E-ISSN 1539-3704, Vol. 139, no 6, 483-487 p.Article in journal (Other academic) Published
Abstract [en]


Antibiotic treatment selects for resistance not only in the pathogen to which it is directed but also in the indigenous microflora.


To determine whether a widely used regimen (clarithromycin, metronidazole, and omeprazole) for Helicobacter pylori eradication affects resistance development in enterococci.


Cohort study.


Endoscopy units at 3 community hospitals in Sweden.


5 consecutive dyspeptic patients who were colonized with H. pylori, had endoscopy-confirmed duodenal ulcer, and received antibiotic treatment, and 5 consecutive controls with dyspepsia but no ulcer who did not receive treatment.


Fecal samples were obtained from patients and controls before, immediately after, 1 year after, and 3 years after treatment. From each patient and sample, enterococci were isolated and analyzed for DNA fingerprint, clarithromycin susceptibility, and presence of the erm(B) gene.


In treated patients, all enterococci isolated immediately after treatment showed high-level clarithromycin resistance due to erm(B). In 3 patients, resistant enterococci persisted for 1 to 3 years after treatment. No resistance developed among controls.


A common H. pylori treatment selects for highly resistant enterococci that can persist for at least 3 years without further selection.

Place, publisher, year, edition, pages
2003. Vol. 139, no 6, 483-487 p.
Keyword [en]
Aged; Aged, 80 and over, Anti-Bacterial Agents/*therapeutic use, Anti-Ulcer Agents/therapeutic use, Clarithromycin/therapeutic use, Drug Resistance; Bacterial, Drug Therapy; Combination, Duodenal Ulcer/drug therapy/microbiology, Enterococcus/*drug effects, Female, Helicobacter Infections/*drug therapy/microbiology, Helicobacter pylori, Humans, Male, Metronidazole/therapeutic use, Middle Aged, Omeprazole/therapeutic use, Prospective Studies, Research Support; Non-U.S. Gov't, Research Support; U.S. Gov't; P.H.S.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-77064PubMedID: 13679325OAI: oai:DiVA.org:uu-77064DiVA: diva2:104976
Available from: 2007-03-13 Created: 2007-03-13 Last updated: 2011-10-13Bibliographically approved

Open Access in DiVA

No full text

Other links


Search in DiVA

By author/editor
Andersson, Dan IEngstrand, Lars
By organisation
Department of Medical SciencesDepartment of Public Health and Caring Sciences
In the same journal
Annals of Internal Medicine
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 297 hits
ReferencesLink to record
Permanent link

Direct link