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Lithium hyaluronate hydrogels enhance osteogenesis in vitro and ex vivo
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström. (polymer chemistry)
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(English)Manuscript (preprint) (Other (popular science, discussion, etc.))
Abstract [en]

Lithium is a clinical drug for bipolar disorders and can enhance bone mass, promote osteogenesis of MSCs through inhibiting the Wnt/β-catenin signalling inhibitor GSK 3β. However, the systemic administration of lithium can trigger severe side-effects. Local administration has been attempted in the treatment of bone defects in animal models with positive outcomes. In this study, we explored a pre-manufactured hydrogel system containing the Li ion (Li-gel) in bone applications. Human MSCs cultured in this Li-gel exhibited enhanced osteogenic differentiation. Furthermore, this Li-gel was used to treat chick embryo chorioallantoic membrane (CAM) femur defects and enhanced the bone healing process. 

Keyword [en]
Lithium, mesenchymal stem cells, bone morphogenetic protein, CAM model.
National Category
Medical Materials
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
URN: urn:nbn:se:uu:diva-307689OAI: oai:DiVA.org:uu-307689DiVA: diva2:1049880
Available from: 2016-11-25 Created: 2016-11-20 Last updated: 2016-12-02
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