Lithium hyaluronate hydrogels enhance osteogenesis in vitro and ex vivo
(English)Manuscript (preprint) (Other (popular science, discussion, etc.))
Lithium is a clinical drug for bipolar disorders and can enhance bone mass, promote osteogenesis of MSCs through inhibiting the Wnt/β-catenin signalling inhibitor GSK 3β. However, the systemic administration of lithium can trigger severe side-effects. Local administration has been attempted in the treatment of bone defects in animal models with positive outcomes. In this study, we explored a pre-manufactured hydrogel system containing the Li ion (Li-gel) in bone applications. Human MSCs cultured in this Li-gel exhibited enhanced osteogenic differentiation. Furthermore, this Li-gel was used to treat chick embryo chorioallantoic membrane (CAM) femur defects and enhanced the bone healing process.
Lithium, mesenchymal stem cells, bone morphogenetic protein, CAM model.
Research subject Engineering Science with specialization in Nanotechnology and Functional Materials
IdentifiersURN: urn:nbn:se:uu:diva-307689OAI: oai:DiVA.org:uu-307689DiVA: diva2:1049880