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Mechanisms and regulation of endothelial VEGF receptor signalling
Yale Cardiovasc Res Ctr, 300 George St, New Haven, CT 06511 USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0003-4723-4173
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
2016 (English)In: Nature reviews. Molecular cell biology, ISSN 1471-0072, E-ISSN 1471-0080, Vol. 17, no 10, 611-625 p.Article, review/survey (Refereed) Published
Abstract [en]

Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely required to balance the formation of new blood vessels with the maintenance and remodelling of existing ones, during development and in adult tissues. Recent advances have greatly expanded our understanding of the tight and multi-level regulation of VEGFR2 signalling, which is the primary focus of this Review. Important insights have been gained into the regulatory roles of VEGFR-interacting proteins (such as neuropilins, proteoglycans, integrins and protein tyrosine phosphatases); the dynamics of VEGFR2 endocytosis, trafficking and signalling; and the crosstalk between VEGF-induced signalling and other endothelial signalling cascades. A clear understanding of this multifaceted signalling web is key to successful therapeutic suppression or stimulation of vascular growth.

Place, publisher, year, edition, pages
2016. Vol. 17, no 10, 611-625 p.
National Category
Cell and Molecular Biology Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-308485DOI: 10.1038/nrm.2016.87ISI: 000384303800008PubMedID: 27461391OAI: oai:DiVA.org:uu-308485DiVA: diva2:1050159
Funder
Swedish Research CouncilSwedish Cancer SocietyKnut and Alice Wallenberg FoundationNIH (National Institute of Health), R01 HL053793 HL084619 P01 HL107205Wenner-Gren Foundations
Available from: 2016-11-28 Created: 2016-11-28 Last updated: 2016-12-07Bibliographically approved

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