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Functional divergence and horizontal transfer of type IV secretion systems
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolution, Genomics and Systematics, Molecular Evolution.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolution, Genomics and Systematics, Molecular Evolution.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolution, Genomics and Systematics, Molecular Evolution.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolution, Genomics and Systematics, Molecular Evolution.
2005 (English)In: Molecular biology and evolution, ISSN 0737-4038, E-ISSN 1537-1719, Vol. 22, no 5, 1325-36 p.Article in journal (Refereed) Published
Abstract [en]

The type IV secretion system (TFSSs) is a multifunctional family of translocation pathways that mediate the transfer of DNA among bacteria and deliver DNA and proteins to eukaryotic cells during bacterial infections. Horizontal transmission has dominated the evolution of the TFSS, as demonstrated here by a lack of congruence between the tree topology inferred from components of the TFSS and the presumed bacterial species divergence pattern. A parsimony analysis suggests that conjugation represents the ancestral state and that the divergence from conjugation to secretion of effector molecules has occurred independently at multiple sites in the tree. The result shows that the nodes at which functional shifts have occurred coincide with those of horizontal gene transfers among distantly related bacteria. We suggest that it is the transfer between species that paved the way for the divergence of the TFSSs and discuss the general role of horizontal gene transfers for the evolution of novel gene functions.

Place, publisher, year, edition, pages
2005. Vol. 22, no 5, 1325-36 p.
Keyword [en]
Bacteria/classification/*genetics, Bacterial Infections/*microbiology, Bacterial Proteins/genetics/*secretion, Conjugation; Genetic, DNA; Bacterial/genetics, Eukaryotic Cells/*microbiology, Evolution; Molecular, Gene Transfer; Horizontal, Phylogeny, Research Support; Non-U.S. Gov't, Virulence
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-77158DOI: 10.1093/molbev/msi124PubMedID: 15746011OAI: oai:DiVA.org:uu-77158DiVA: diva2:105070
Available from: 2006-03-13 Created: 2006-03-13 Last updated: 2011-02-18Bibliographically approved

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Frank, CarolinThollesson, MikaelAndersson, Siv

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