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Intracerebroventricular Oxytocin Self-Administration in Female Rats
Univ Southern Calif, Grad Program Neurosci, Los Angeles, CA 90033 USA..
Univ Southern Calif, Grad Program Neurosci, Los Angeles, CA 90033 USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Univ Southern Calif, Keck Sch Med, Dept Cell & Neurobiol, 1333 San Pablo St,BMT 408a, Los Angeles, CA 90033 USA.
Univ Southern Calif, Keck Sch Med, Dept Cell & Neurobiol, 1333 San Pablo St,BMT 408a, Los Angeles, CA 90033 USA..
2016 (English)In: Journal of neuroendocrinology (Print), ISSN 0953-8194, E-ISSN 1365-2826, Vol. 28, no 10Article in journal (Refereed) Published
Abstract [en]

Oxytocin (OT) is a neuromodulator that facilitates pair-bonding, maternal care and social approach. OT is considered to promote these social behaviours by enhancing the salience and reinforcing effects of relevant social stimuli. There is the additional possibility that OT per se may be rewarding. To test this, we investigated whether female rats would voluntarily self-administer OT. Female Long-Evans rats were ovariectomised and then received an oestrogen implant and an i.c.v. cannula. Rats were tested in an operant chamber with active and inactive levers. They were initially tested for 4h/day on a fixed-ratio 5 schedule for self-administration of artificial cerebral spinal fluid (aCSF) for 5days, followed by aCSF, or OT, at 1 or 10ng/l for another 5days. Rats self-administering aCSF made 36.2 +/- 6.2 active lever responses/4h versus 14.9 +/- 3.4 inactive responses. Responses for 1ng/l OT were similar. However, rats self-administering 10ng/l OT made significantly more active lever responses (67.8 +/- 12.0 per 4h), and received 121.4 +/- 21.0ng OT/4h. To determine whether reduced anxiety contributes to the reinforcing effects of OT, rats received an infusion of aCSF or OT at 0.3 or 3.0g immediately before testing on the elevated plus maze. There was no effect of OT on anxiety as reflected by percentage time spent on the open arms, as well as no effect of OT on locomotion as measured either by the number of closed arm entries or the number of total arm entries. These results suggest that OT may be rewarding, and that this is not a result of the anxiolytic effects of OT.

Place, publisher, year, edition, pages
2016. Vol. 28, no 10
Keywords [en]
oxytocin, self-administration, intracerebroventricular, operant behaviour, reinforcement, rats
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-308936DOI: 10.1111/jne.12416ISI: 000387066900005OAI: oai:DiVA.org:uu-308936DiVA, id: diva2:1051314
Funder
NIH (National Institute of Health), R21-AA020575Available from: 2016-12-01 Created: 2016-12-01 Last updated: 2017-11-29Bibliographically approved

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