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Sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes
Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Transplantation and regenerative medicine.
Lund Univ, Dept Clin Sci, Malmo, Sweden..
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2016 (English)In: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 175, no 6, p. 605-614Article in journal (Refereed) Published
Abstract [en]

Objective: Sweetened beverage intake is associated with increased risk of type 2 diabetes, but its association with autoimmune diabetes is unclear. We aimed to investigate sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA); autoimmune diabetes with features of type 2 diabetes. Design/methods: Data from a Swedish population-based study was used, including incident cases of LADA (n = 357) and type 2 diabetes (n = 1136) and randomly selected controls (n = 1371). Diabetes classification was based on onset age (= 35), glutamic acid decarboxylase autoantibodies (GADA) and C-peptide. Sweetened beverage intake information was derived from a validated food frequency questionnaire. ORs adjusted for age, sex, family history of diabetes, education, lifestyle, diet, energy intake and BMI were estimated using logistic regression. Results: Daily intake of >2 servings of sweetened beverages (consumed by 6% of participants) was associated with increased risk of LADA (OR: 1.99, 95% CI: 1.11-3.56), and for each 200 mL daily serving, OR was 1.15 (95% CI: 1.02-1.29). Findings were similar for sugar-sweetened (OR: 1.18, 95% CI: 1.00-1.39) and artificially sweetened beverages (OR: 1.12, 95% CI: 0.95-1.32). Similarly, each daily serving increment in total sweetened beverage conferred 20% higher type 2 diabetes risk (95% CI: 1.07-1.34). In type 2 diabetes patients, high consumers displayed higher HOMA-IR levels (4.5 vs 3.5, P = 0.0002), but lower HOMA-B levels (55 vs 70, P = 0.0378) than non-consumers. Similar tendencies were seen in LADA. Conclusions: High intake of sweetened beverages was associated with increased risk of LADA. The observed relationship resembled that with type 2 diabetes, suggesting common pathways possibly involving insulin resistance.

Place, publisher, year, edition, pages
2016. Vol. 175, no 6, p. 605-614
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-308887DOI: 10.1530/EJE-16-0376ISI: 000386915600017OAI: oai:DiVA.org:uu-308887DiVA, id: diva2:1051350
Funder
Swedish Research CouncilForte, Swedish Research Council for Health, Working Life and WelfareAFA InsuranceSwedish Diabetes AssociationAvailable from: 2016-12-01 Created: 2016-12-01 Last updated: 2017-11-29Bibliographically approved

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Carlsson, Per-OlaMartinell, Mats

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