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Carbon-11, Nitrogen-13, and Oxygen-15 Chemistry: An Introduction to Chemistry with Short-Lived Radioisotopes
Department of Chemistry, Imperial College London, London, UK.
Department of Molecular Imaging, National Centre of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Physical Organic Chemistry.
2015 (English)In: The Chemistry of Molecular Imaging / [ed] Nicholas Long and Wing-Tak Wong, Wiley-Blackwell, 2015, p. 79-103Chapter in book (Refereed)
Abstract [en]

This chapter first introduces the field of carbon-11, nitrogen-13, and oxygen-15 chemistry, and then provides an up-to-date account of their chemistry. The carbon-11 isotope is most widely produced by the proton bombardment of nitrogen-14 in a gas phase cyclotron target. 11CO2 is the most widely produced in target C-11 primary precursor. Methylation reactions are commonly used for the production of many of the key 11C-tracers. Palladium-mediated C-11 carbonylation reactions are most widely exploited and used to effectively label imides, ketones, carboxylic acids, esters, amides, and acrylamides. N-13 labelled amines are of interest for improving positron emission tomography (PET) myocardial perfusion imaging and representing their metabolism. Oxygen-15 is generally produced in target via the bombardment of nitrogen gas with deuterons. The majority of O-15 chemistry is therefore based on the production of small molecules either directly within the cyclotron target or via one chemical transformation using high temperature gas phase methods.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2015. p. 79-103
Keyword [en]
Carbon-11 chemistry, Carbonylation reactions, Methylation reactions, Nitrogen-13 chemistry, Oxygen-15 chemistry, Positron emission tomography (PET)
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-307073DOI: 10.1002/9781118854754.ch4Scopus ID: 2-s2.0-84926246210ISBN: 9781118854754 (print)ISBN: 9781118093276 (print)OAI: oai:DiVA.org:uu-307073DiVA: diva2:1051476
Available from: 2016-12-02 Created: 2016-11-08 Last updated: 2016-12-02Bibliographically approved

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Långstrom, Bengt

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