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Evidence for a Link Between Fkbp5/FKBP5, Early Life Social Relations and Alcohol Drinking in Young Adult Rats and Humans
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
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2017 (English)In: Molecular Neurobiology, ISSN 0893-7648, E-ISSN 1559-1182, Vol. 54, no 8, p. 6225-6234Article in journal (Refereed) Published
Abstract [en]

Alcohol misuse has been linked to dysregulation of stress, emotion, and reward brain circuitries. A candidate key mediator of this association is the FK506-binding protein (FKBP5), a negative regulator of the glucocorticoid receptor. The aim of the present study was to further understand the Fkbp5/FKBP5-related genetic underpinnings underlying the relationship between early life social relations and alcohol drinking. The effect of maternal separation and voluntary alcohol drinking on Fkbp5 expression was investigated in the brain of young adult rats, whereas the interaction effect of the functional FKBP5 single nucleotide polymorphism rs1360780 genotype and parent-child relationship on problematic drinking was examined in young adult humans. In rats, Fkbp5 expression in the nucleus accumbens and ventral tegmental area, core regions of the reward system, was affected in a region-dependent manner and in opposite direction by maternal separation and alcohol drinking. Fkbp5 expression in the cingulate cortex was affected by the combined effect of maternal separation and alcohol drinking. In humans, the TT genotype, in the presence of a poor relationship between the child and parents, was associated with problematic drinking behavior. The present findings suggest that Fkbp5 expression in mesocorticolimbic dopaminergic regions associates with early life stress-mediated sensitivity to alcohol drinking and that FKBP5 genotype interacts with parent-child relationship to influence alcohol drinking. These findings are the first to point to a role of FKBP5 in propensity to alcohol misuse and call for studies of the underlying molecular mechanisms to identify potential drug targets.

Place, publisher, year, edition, pages
2017. Vol. 54, no 8, p. 6225-6234
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-309060DOI: 10.1007/s12035-016-0157-zISI: 000409039000040PubMedID: 27709495OAI: oai:DiVA.org:uu-309060DiVA: diva2:1051513
Funder
Lars Hierta Memorial FoundationThe Swedish Brain FoundationSwedish Research Council, K2012-61X-22090-01-3, 2015-00495Forte, Swedish Research Council for Health, Working Life and WelfareEU, FP7, Seventh Framework Programme, INCA 600398
Available from: 2016-12-02 Created: 2016-12-02 Last updated: 2018-01-03Bibliographically approved

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Nylander, IngridTodkar, AniruddhaGranholm, LinneaVrettou, MariaBendre, MeghaComasco, Erika

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Nylander, IngridTodkar, AniruddhaGranholm, LinneaVrettou, MariaBendre, MeghaNilsson, Kent WComasco, Erika
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Department of Pharmaceutical BiosciencesDepartment of NeuroscienceNeuro-psycho-pharmacology
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