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Neuroimaging the Menstrual Cycle and Premenstrual Dysphoric Disorder
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
2015 (English)In: Current Psychiatry Reports, ISSN 1523-3812, E-ISSN 1535-1645, Vol. 17, no 10, 77Article, review/survey (Refereed) Published
Abstract [en]

Knowledge of gonadal hormone-related influences on human brain anatomy, function, and chemistry is scarce. The present review scrutinized organizational and functional neuroimaging correlates of the menstrual cycle and premenstrual dysphoric disorder (PMDD). Supportive evidence of cyclic short-term structural and functional brain plasticity in response to gonadal hormonal modulation is provided. The paucity of studies, sparsity and discordance of findings, and weaknesses in study design at present hinder the drawing of firm conclusions. Ideal study designs should comprise high-resolution multimodal neuroimaging (e.g., MRI, DTI, rsfMRI, fMRI, PET), hormones, genetic, and behavioral longitudinal assessments of healthy women and PMDD patients at critical time points of the menstrual cycle phase (i.e., early follicular phase, late follicular phase, mid-luteal phase) in a counter-balanced setup. Studies integrating large-scale brain network structural, functional, and molecular neuroimaging, as well as treatment data, will deepen the understanding of neural state, disorder, and treatment markers.

Place, publisher, year, edition, pages
2015. Vol. 17, no 10, 77
Keyword [en]
Estrogen, fMRI, Menstrual cycle, PET, PMDD, Progesterone, Women
National Category
URN: urn:nbn:se:uu:diva-309070OAI: oai:DiVA.org:uu-309070DiVA: diva2:1051528
Swedish Society of Medicine, SLS-331991Swedish Research Council, 521-2013-2339
Available from: 2016-12-02 Created: 2016-12-02 Last updated: 2016-12-02

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