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Inflammasomes of the intestinal epithelium
Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.
Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.
Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.
2015 (English)In: Trends in immunology, ISSN 1471-4906, E-ISSN 1471-4981, Vol. 36, no 8, 442-450 p.Article in journal (Refereed) Published
Abstract [en]

While the functional importance of inflammasomes in blood-derived cell types is well established, it remains poorly understood how inflammasomes in nonhematopoietic cells contribute to mucosal immunity. Recent studies have revealed functional roles of inflammasomes - particularly NAIP/NLRC4, NLRP6, and noncanonical caspase-4 (caspase-11) - within epithelial cells of the gut in mucosal immune defense, inflammation, and tumorigenesis. Here, we review and discuss these findings in the broader context of tissue compartment-specific mucosal immunity. We propose several models whereby activities of the intestinal epithelial inflammasomes converge on mechanisms to remove compromised epithelial cells, maintain host-microbiota mutualism, and communicate with immune cells of the underlying lamina propria.

Place, publisher, year, edition, pages
2015. Vol. 36, no 8, 442-450 p.
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-309864DOI: 10.1016/j.it.2015.06.002ISI: 000359882900003PubMedID: 26166583OAI: oai:DiVA.org:uu-309864DiVA: diva2:1053046
Funder
Swedish Research Council, 2012-262Wellcome trust, 102972
Available from: 2016-12-08 Created: 2016-12-08 Last updated: 2016-12-09Bibliographically approved

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