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Uni-directional polymerization leading to homochirality in the RNA world
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Astronomy and Space Physics.
2005 (English)In: International Journal of Astrobiology, Vol. 4, 233-239 p.Article in journal (Refereed) Published
Abstract [en]

The differences between uni-directional and bi-directional polymerization are considered. The uni-directional case is discussed in the framework of the RNA world. Similar to earlier models of this type, where polymerization was assumed to proceed in a bi-directional fashion (presumed to be relevant to peptide nucleic acids), left-handed and right-handed monomers are produced via an autocatalysis from an achiral substrate. The details of the bifurcation from a racemic solution to a homochiral state of either handedness is shown to be remarkably independent of whether the polymerization in uni-directional or bi-directional. Slightly larger differences are seen when dissociation is allowed and the dissociation fragments are being recycled into the achiral substrate.

Place, publisher, year, edition, pages
2005. Vol. 4, 233-239 p.
Keyword [en]
enantiomeric cross-inhibition, origin of homochirality, RNA and DNA polymerization
URN: urn:nbn:se:uu:diva-77496DOI: doi:10.1017/S1473550405002752OAI: oai:DiVA.org:uu-77496DiVA: diva2:105408
Available from: 2006-03-14 Created: 2006-03-14 Last updated: 2011-01-11

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